Gene Symbol | CACNA1S |
---|---|
Entrez Gene | 779 |
Alt Symbol | CACNL1A3, CCHL1A3, Cav1.1, HOKPP, HOKPP1, MHS5, TTPP1, hypoPP |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, L type, alpha 1S subunit |
Other Description | calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis)|dihydropyridine receptor|dihydropyridine-sensitive L-type calcium channel alpha-1 subunit|voltage-dependent L-type calcium channel subunit alpha-1S|voltage-gated calcium channel subunit alpha Cav1.1 |
Swissprots | Q13934 A4IF51 Q12896 B1ALM2 Q13698 |
Accessions | AAB37235 EAW91333 EAW91334 EAW91335 Q13698 BC133671 AAI33672 L33798 AAA51902 U09784 AAA20531 U14413 AAC50397 U18986 AAC50398 XM_005245478 XP_005245535 NM_000069 NP_000060 |
Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Skeletal muscle specific. |
Top Pathways | Alzheimer's disease, Arrhythmogenic right ventricular cardiomyopathy (ARVC), cAMP signaling pathway, MAPK signaling pathway, Calcium signaling pathway |
L-type Ca ++ CP α1S (N-19) - sc-8160 from Santa Cruz Biotechnology
|
||||||||||
L-type Ca ++ CP α1S (IIF71VH3) - sc-21782 from Santa Cruz Biotechnology
|
||||||||||
L-type Ca ++ CP α1S (C-17) - sc-16257 from Santa Cruz Biotechnology
|
||||||||||
L-type Ca ++ CP α1S (IIC12D4) - sc-21781 from Santa Cruz Biotechnology
|
||||||||||
L-type Ca ++ CP α1S (H-263) - sc-20814 from Santa Cruz Biotechnology
|
||||||||||
L-type Ca ++ CP α1S (Y-18) - sc-16256 from Santa Cruz Biotechnology
|
||||||||||
Anti-CACNA1S antibody - ab96413 from Abcam
|
||||||||||
Anti-CACNA1S antibody - ab203662 from Abcam
|
||||||||||
Anti-CACNA1S antibody - ab106343 from Abcam
|
||||||||||
Anti-CACNA1S antibody [1A] - ab2862 from Abcam
|
||||||||||
Anti-CACNA1S antibody [mAB 1a] - ab78003 from Abcam
|
||||||||||
Anti-CACNA1S / Cav1.1 Antibody - LS-C22829 from LifeSpan Bioscience
|
||||||||||
Anti-CACNA1S / Cav1.1 Antibody - LS-C152942 from LifeSpan Bioscience
|
||||||||||
Anti-CACNA1S / Cav1.1 Antibody (clone 2C5) - LS-C196799 from LifeSpan Bioscience
|
||||||||||
Anti-CACNA1S / Cav1.1 Antibody (aa544-885) - LS-C185510 from LifeSpan Bioscience
|
||||||||||
CACNA1S Antibody (1A) - NB300-542 from Novus Biologicals
|
||||||||||
CACNA1S Antibody - NBP2-33541 from Novus Biologicals
|
||||||||||
CACNA1S Antibody - NBP1-31659 from Novus Biologicals
|
||||||||||
CACNA1S Antibody (mAB 1a) - NBP2-29825 from Novus Biologicals
|
||||||||||
CACNA1S Antibody - NBP1-30675 from Novus Biologicals
|
||||||||||
CACNA1S Antibody - NBP2-33799 from Novus Biologicals
|
||||||||||
CACNA1S Antibody (2C5) - H00000779-M01 from Novus Biologicals
|
||||||||||
CACNA1S Antibody - H00000779-A01 from Novus Biologicals
|
||||||||||
CACNA1S Polyclonal Antibody - bs-9925R from Bioss
|
||||||||||
Monoclonal Anti-Dihydropyridine Receptor (α1 Subunit) antibody produced in mouse - D218 from Sigma-Aldrich
|