| Gene Symbol |
ZBTB16
|
| Entrez Gene |
7704
|
| Alt Symbol |
PLZF, ZNF145
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger and BTB domain containing 16
|
| Other Description |
promyelocytic leukaemia zinc finger|zinc finger and BTB domain-containing protein 16|zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)|zinc finger protein PLZF
|
| Swissprots |
Q05516 Q8TAL4
|
| Accessions |
AAC32847 AAC32848 AAC32849 AAC60590 AAD03619 EAW67241 EAW67242 Q05516 AB208916 BAD92153 AK126422 BC026902 AAH26902 BC029812 AAH29812 BM969145 BX648973 EU446725 ABZ92254 Z19002 CAA79489 XM_005271658 XP_005271715 XM_011542971 XP_011541273 NM_001018011 NP_001018011 NM_006006 NP_005997
|
| Function |
Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:14528312}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
|
| Top Pathways |
Acute myeloid leukemia, Transcriptional misregulation in cancer
|