ZBTB16

Gene Symbol ZBTB16
Entrez Gene 7704
Alt Symbol PLZF, ZNF145
Species Human
Gene Type protein-coding
Description zinc finger and BTB domain containing 16
Other Description promyelocytic leukaemia zinc finger|zinc finger and BTB domain-containing protein 16|zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)|zinc finger protein PLZF
Swissprots Q05516 Q8TAL4
Accessions AAC32847 AAC32848 AAC32849 AAC60590 AAD03619 EAW67241 EAW67242 Q05516 AB208916 BAD92153 AK126422 BC026902 AAH26902 BC029812 AAH29812 BM969145 BX648973 EU446725 ABZ92254 Z19002 CAA79489 XM_005271658 XP_005271715 XM_011542971 XP_011541273 NM_001018011 NP_001018011 NM_006006 NP_005997
Function Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:14528312}.
Subcellular Location Nucleus.
Tissue Specificity Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
Top Pathways Acute myeloid leukemia, Transcriptional misregulation in cancer

PLZF (H-300) - sc-22839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PLZF (H-300): sc-22839. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

PLZF (D-9) - sc-28319 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PLZF (D-9): sc-28319. Immunoperoxidase staining of formalin fixed, paraffin-embedded human thyroid gland tissue showing nuclear staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

PLZF (N-21) - sc-11146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PLZF (N-21): sc-11146. Western blot analysis of PLZF expression in non-transfected: sc-117752 (A) and human PLZF transfected: sc-113938 (B) 293T whole cell lysates.

Anti-Plzf antibody - ab134780 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Plzf antibody (ab134780) at 1/1000 dilution + HeLa whole cell extract

Anti-Plzf antibody - ab111951 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Plzf antibody (ab111951) at 1/1000 dilutionLane 1 : Human fetal muscle lysateLane 2 : Human fetal spleen lysate

Anti-Plzf antibody [5B3] - ab104854 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B3
Anti-Plzf antibody [5B3] (ab104854) at 1/500 dilution + HeLa cell lysate

Anti-Plzf antibody - N-terminal - ab189849 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Plzf antibody - N-terminal (ab189849) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : THP1 cell extractLane 3 : Mouse lung extractLane 4 : Mouse heart extractLane 5 : Mouse brain extract

Anti-ZBTB16 / PLZF Antibody (aa1-254, clone TS106) - LS-C191502 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TS106

Anti-ZBTB16 / PLZF Antibody (Tyr334, AP) - LS-C284456 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody (phospho-Tyr334) - LS-C97095 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of anti-Phospho-ZBTB16-pY334 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Anti-ZBTB16 / PLZF Antibody (Tyr334, FITC) - LS-C284457 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody (Tyr334, Azide-free, HRP) - LS-C284458 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody (Tyr334, Biotin) - LS-C284459 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody (Tyr334, APC) - LS-C284550 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody (aa637-666) - LS-C98399 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of PLZF Antibody in 293, K562 cell line lysates (35 ug/lane). PLZF (arrow) was detected using the purified antibody.

Anti-ZBTB16 / PLZF Antibody (Tyr334, PE) - LS-C284460 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody (phospho-Tyr334) - LS-C329149 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody (clone 1F10) - LS-C139369 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F10
Detection limit for recombinant GST tagged ZBTB16 is approximately 0.03 ng/ml as a capture antibody.

Anti-ZBTB16 / PLZF Antibody (C-Terminus) - LS-C80227 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-ZBTB16 / PLZF Antibody (aa389-658) - LS-C178550 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody - LS-C341917 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ZBTB16 / PLZF Antibody - LS-C334349 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using ZBTB16 antibody.

Anti-ZBTB16 / PLZF Antibody (clone 5B3) IHC-plus™ - LS-B8737 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 5B3
Anti-ZBTB16 / PLZF antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PLZF Antibody (6318100) [Unconjugated] - MAB2944 from Novus Biologicals

Prices $99.00, $259.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 6318100
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, HEL 92.1.7 human erythroleukemic cell line, LNCaP human prostate cancer cell line, and 293T human embryonic kidney cell line. PVDF Membrane was probed with 1 µg/mL of Human PLZF Monoclonal Antibody (Catalog # MAB2944) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PLZF at approximately 85 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PLZF Antibody (816416) - MAB8395 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 816416
Western blot shows lysates of BaF3 mouse pro-B cell line and KG‑1 human acute myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Rat Anti-Mouse PLZF Monoclonal Antibody (Catalog # MAB8395) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for PLZF at approximately 75 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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