| Gene Symbol |
CIART
|
| Entrez Gene |
148523
|
| Alt Symbol |
C1orf51, CHRONO, GM129
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
circadian associated repressor of transcription
|
| Other Description |
chIP-derived repressor of network oscillator|circadian-associated transcriptional repressor|computationally highlighted repressor of the network oscillator
|
| Swissprots |
D3DV01 Q8N795 Q8N365 Q96MG6 B2RD43
|
| Accessions |
CAI22816 CAI22817 CAI22818 CAI22819 EAW53560 EAW53561 EAW53562 EAW53563 EAW53564 Q8N365 AK056960 BAB71326 AK098755 BAC05404 AK315397 BAG37790 BC017397 AAH17397 BC027999 AAH27999 BC047238 AAH47238 BE784098 CK904668 CN359562 EB388133 GQ129400 ACT64534 GQ129401 ACT64535 HQ447253 ADQ31740 NM_001300838 NP_001287767 NM_001300839 NP_001287768 NM_001300840 NP_001287769 NM_001300841 NP_001287770 NM_144697 NP_653298
|
| Function |
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. {ECO:0000250}.
|