CIART

Gene Symbol	CIART
Entrez Gene	148523
Alt Symbol	C1orf51, CHRONO, GM129
Species	Human
Gene Type	protein-coding
Description	circadian associated repressor of transcription
Other Description	chIP-derived repressor of network oscillator|circadian-associated transcriptional repressor|computationally highlighted repressor of the network oscillator
Swissprots	D3DV01 Q8N795 Q8N365 Q96MG6 B2RD43
Accessions	CAI22816 CAI22817 CAI22818 CAI22819 EAW53560 EAW53561 EAW53562 EAW53563 EAW53564 Q8N365 AK056960 BAB71326 AK098755 BAC05404 AK315397 BAG37790 BC017397 AAH17397 BC027999 AAH27999 BC047238 AAH47238 BE784098 CK904668 CN359562 EB388133 GQ129400 ACT64534 GQ129401 ACT64535 HQ447253 ADQ31740 NM_001300838 NP_001287767 NM_001300839 NP_001287768 NM_001300840 NP_001287769 NM_001300841 NP_001287770 NM_144697 NP_653298
Function	Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human C1orf51 full length protein - ab198673 from Abcam Category Protein Prices $382.00 Sizes 20 µg Source E. coli Species Human

CIART / C1orf51 Antibody Blocking Peptide - LS-E184 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CIART / C1orf51 Antibody Blocking Peptide - LS-E18995 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

C1orf51-Antibody-N-term-Blocking-peptide - BP10380a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

C1orf51 Blocking Peptide - 33R-3526 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

C1orf51 fusion protein - Ag15364 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

C1orf51 fusion protein - Ag15634 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human C1orf51, GST-tagged - C1orf51-10466H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Uncharacterized protein C1orf51(C1orf51) - CSB-YP850790HU CSB-EP850790HU CSB-BP850790HU CSB-MP850790HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

C1orf51 Recombinant Protein Antigen - NBP1-88685PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

C1ORF51 Peptide, Human - M34GP01900H from Creative Peptides Category Peptide Source Synthetic. Species Human

C1orf51 Recombinant Protein Antigen - NBP2-55476PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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