| Gene Symbol |
UCN
|
| Entrez Gene |
7349
|
| Alt Symbol |
UI, UROC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
urocortin
|
| Other Description |
prepro-urocortin|urocortin, preproprotein
|
| Swissprots |
P55089 Q6FG64
|
| Accessions |
AAC24204 AAY24297 EAX00605 P55089 BC104470 AAI04471 BC104471 AAI04472 CR542244 CAG47040 NM_003353 NP_003344
|
| Function |
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). {ECO:0000250|UniProtKB:P55090, ECO:0000250|UniProtKB:P81615, ECO:0000269|PubMed:8612563}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481). {ECO:0000269|PubMed:10690896, ECO:0000269|PubMed:15531481}.
|