Gene Symbol | UCN |
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Entrez Gene | 7349 |
Alt Symbol | UI, UROC |
Species | Human |
Gene Type | protein-coding |
Description | urocortin |
Other Description | prepro-urocortin|urocortin, preproprotein |
Swissprots | P55089 Q6FG64 |
Accessions | AAC24204 AAY24297 EAX00605 P55089 BC104470 AAI04471 BC104471 AAI04472 CR542244 CAG47040 NM_003353 NP_003344 |
Function | Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). {ECO:0000250|UniProtKB:P55090, ECO:0000250|UniProtKB:P81615, ECO:0000269|PubMed:8612563}. |
Subcellular Location | Secreted. |
Tissue Specificity | Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481). {ECO:0000269|PubMed:10690896, ECO:0000269|PubMed:15531481}. |
Urocortin-human - SP3625b from Abgent, a WuXi AppTec company
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Urocortin-human - SP3625a from Abgent, a WuXi AppTec company
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Urocortin peptide - orb72016 from Biorbyt
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UCN peptide - orb72247 from Biorbyt
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Urocortin Peptide - abx064762 from Abbexa
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UCN fusion protein - Ag15995 from Proteintech Group
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Urocortin, human - 52314 from NeoScientific
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Urocortin (rat) (free acid) - 89721 from NeoScientific
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Urocortin Peptide - 350418 from ABBIOTEC
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Recombinant Human UCN, GST-tagged - UCN-3577H from Creative Biomart
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Recombinant Urocortin 1 (UCN1) - RPA231Cp01 from Uscn Life Science Inc.
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Urocortin; Human - CCP1463 from Cohesion Biosciences
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Urocortin; Rat - CCP1464 from Cohesion Biosciences
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UCN (A103) Peptide - BS1488P from Bioworld Technology
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OVA Conjugated Urocortin 1 (UCN1) - CPA231Mi21 from Cloud-clone
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Recombinant Human Urocortin(UCN) - CSB-YP025551HU CSB-EP025551HU CSB-BP025551HU CSB-MP025551HU from Cusabio
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Urocortin (human) - 1604 from R&D Systems
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Urocortin, Peptide - MBS826658 from MyBioSource
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Urocortin, Peptide - MBS658477 from MyBioSource
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Urocortin, Peptide - MBS658479 from MyBioSource
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Urocortin, Peptide - MBS659863 from MyBioSource
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Urocortin, Peptide - MBS826278 from MyBioSource
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Urocortin - abx265047 from Abbexa
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UCN Peptide, Human - M34GP17028H from Creative Peptides
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Urocortin, human - U02002 from Creative Peptides
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