| Gene Symbol |
ARIH1
|
| Entrez Gene |
25820
|
| Alt Symbol |
ARI, HARI, HHARI, UBCH7BP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ariadne RBR E3 ubiquitin protein ligase 1
|
| Other Description |
ARI-1|E3 ubiquitin-protein ligase ARIH1|H7-AP2|MOP-6|ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1|ariadne, Drosophila, homolog of|monocyte protein 6|protein ariadne-1 homolog|ubcH7-binding protein|ubcM4-interacting protein|ubiquitin-conjugating enzyme E2-binding protein 1
|
| Swissprots |
Q9UP39 Q9H3T6 O76026 B2R6U3 Q9UEN0 Q9Y4X5
|
| Accessions |
CAH05382 EAW77907 EAW77908 Q9Y4X5 AB014774 BAB19786 AB209432 BAD92669 AF072832 AAD28088 AJ009771 CAA08817 AJ130976 CAA10274 AJ243190 CAB45870 AK000336 AK312715 BAG35590 AL117650 BC051877 AAH51877 BX641117 XM_011521438 XP_011519740 XM_011521439 XP_011519741 NM_005744 NP_005735
|
| Function |
E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. {ECO:0000269|PubMed:14623119, ECO:0000269|PubMed:15236971, ECO:0000269|PubMed:17289916, ECO:0000269|PubMed:21532592}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11278816}. Note=Mainly cytoplasmic.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10521492}.
|