Gene Symbol | CSNK2A2 |
---|---|
Entrez Gene | 1459 |
Alt Symbol | CK2A2, CSNK2A1 |
Species | Human |
Gene Type | protein-coding |
Description | casein kinase 2, alpha prime polypeptide |
Other Description | CK II alpha'|casein kinase II subunit alpha' |
Swissprots | P19784 |
Accessions | EAW82969 P19784 AI150700 AK090752 AK125922 BC008812 AAH08812 DQ893025 ABM83951 DQ896269 ABM87268 M55268 AAA51548 XM_005255800 XP_005255857 XM_005255801 XP_005255858 NM_001896 NP_001887 |
Function | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat |
Top Pathways | Wnt signaling pathway, Adherens junction, Tight junction, Ribosome biogenesis in eukaryotes, Measles |
casein kinase IIα′ (C-20) - sc-6481 from Santa Cruz Biotechnology
|
||||||||
casein kinase IIα′ (D-7) - sc-514403 from Santa Cruz Biotechnology
|
||||||||
Anti-CKII alpha prime polypeptide antibody - ab116377 from Abcam
|
||||||||
Anti-CKII alpha prime polypeptide antibody - ab124360 from Abcam
|
||||||||
Anti-CKII alpha prime polypeptide antibody [1E1] - ab135245 from Abcam
|
||||||||
Anti-CSNK2A2 Antibody - LS-C83020 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (C-Terminus) - LS-C81756 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa3-32, APC) - LS-C255553 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa3-32, AP) - LS-C255555 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa3-32, Biotin) - LS-C255556 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa69-310) - LS-C178877 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa3-32, FITC) - LS-C255557 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa3-32, Azide-free, HRP) - LS-C255558 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa3-32, PE) - LS-C255559 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody - LS-C192741 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa1-100) - LS-C307109 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (clone 4F2) - LS-C196986 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (clone 1E1) - LS-C169119 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (Biotin) - LS-C318495 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody - LS-C310017 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (HRP) - LS-C318499 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (FITC) - LS-C318497 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody (aa3-32) - LS-C164358 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody - LS-C318500 from LifeSpan Bioscience
|
||||||||
Anti-CSNK2A2 Antibody - LS-C331589 from LifeSpan Bioscience
|