| Gene Symbol | CSNK2A2 |
|---|---|
| Entrez Gene | 1459 |
| Alt Symbol | CK2A2, CSNK2A1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | casein kinase 2, alpha prime polypeptide |
| Other Description | CK II alpha'|casein kinase II subunit alpha' |
| Swissprots | P19784 |
| Accessions | EAW82969 P19784 AI150700 AK090752 AK125922 BC008812 AAH08812 DQ893025 ABM83951 DQ896269 ABM87268 M55268 AAA51548 XM_005255800 XP_005255857 XM_005255801 XP_005255858 NM_001896 NP_001887 |
| Function | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat |
| Top Pathways | Wnt signaling pathway, Adherens junction, Tight junction, Ribosome biogenesis in eukaryotes, Measles |