| Gene Symbol |
NCR2
|
| Entrez Gene |
9436
|
| Alt Symbol |
CD336, LY95, NK-p44, NKP44, dJ149M18.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
natural cytotoxicity triggering receptor 2
|
| Other Description |
NK cell activating receptor (NKp44)|NK cell-activating receptor|lymphocyte antigen 95 (activating NK-receptor; NK-p44)|lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44)|natural killer cell p44-related protein
|
| Swissprots |
Q9H562 O95944 Q9UMT2 Q9H563 Q9UMT1 Q9H564
|
| Accessions |
EAX04039 EAX04040 EAX04041 EAX04042 O95944 AJ010099 CAB52289 AJ010100 CAB52290 BC166647 AAI66647 NM_001199509 NP_001186438 NM_001199510 NP_001186439 NM_004828 NP_004819
|
| Function |
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269|PubMed:10049942}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells. {ECO:0000269|PubMed:10049942}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|
![Western Blot: NCR2 Overexpression Lysate (Adult Normal) [NBL1-13520] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NCR2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5039_NCR2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13520-img0002.jpg)