Gene Symbol | NCR2 |
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Entrez Gene | 9436 |
Alt Symbol | CD336, LY95, NK-p44, NKP44, dJ149M18.1 |
Species | Human |
Gene Type | protein-coding |
Description | natural cytotoxicity triggering receptor 2 |
Other Description | NK cell activating receptor (NKp44)|NK cell-activating receptor|lymphocyte antigen 95 (activating NK-receptor; NK-p44)|lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44)|natural killer cell p44-related protein |
Swissprots | Q9H562 O95944 Q9UMT2 Q9H563 Q9UMT1 Q9H564 |
Accessions | EAX04039 EAX04040 EAX04041 EAX04042 O95944 AJ010099 CAB52289 AJ010100 CAB52290 BC166647 AAI66647 NM_001199509 NP_001186438 NM_001199510 NP_001186439 NM_004828 NP_004819 |
Function | Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269|PubMed:10049942}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells. {ECO:0000269|PubMed:10049942}. |
Top Pathways | Natural killer cell mediated cytotoxicity |
NKp44 CRISPR/Cas9 KO Plasmid (h) - sc-407295 from Santa Cruz Biotechnology
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NKp44 HDR Plasmid (h) - sc-407295-HDR from Santa Cruz Biotechnology
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NKp44 Double Nickase Plasmid (h) - sc-407295-NIC from Santa Cruz Biotechnology
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NKp44 Double Nickase Plasmid (h2) - sc-407295-NIC-2 from Santa Cruz Biotechnology
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NKp44 CRISPR Activation Plasmid (h) - sc-407295-ACT from Santa Cruz Biotechnology
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NKp44 CRISPR Activation Plasmid (h2) - sc-407295-ACT-2 from Santa Cruz Biotechnology
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NKp44 Lentiviral Activation Particles (h) - sc-407295-LAC from Santa Cruz Biotechnology
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NKp44 Lentiviral Activation Particles (h2) - sc-407295-LAC-2 from Santa Cruz Biotechnology
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NKp44 siRNA (h) - sc-72170 from Santa Cruz Biotechnology
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NKp44 shRNA Plasmid (h) - sc-72170-SH from Santa Cruz Biotechnology
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NKp44 shRNA (h) Lentiviral Particles - sc-72170-V from Santa Cruz Biotechnology
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NKp44/NCR2 RNAi - H00009436-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15037 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15037 from Sigma-Aldrich
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NCR2 siRNA (Human) - CRH6256 from Cohesion Biosciences
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NKp44 CRISPR/Cas9 KO Plasmid (h2) - sc-407295-KO-2 from Santa Cruz Biotechnology
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NKp44 HDR Plasmid (h2) - sc-407295-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human NCR2 (NM_004828.3) - SHH350192 from Creative biogene
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NCR2 shRNA Plasmid (Human) - CHH6256 from Cohesion Biosciences
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NCR2 miRNA 3'UTR clone - MiUTR1H-06689 from Creative biogene
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