| Gene Symbol |
DIS3L2
|
| Entrez Gene |
129563
|
| Alt Symbol |
FAM6A, PRLMNS, hDIS3L2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DIS3 like 3'-5' exoribonuclease 2
|
| Other Description |
DIS3 mitotic control homolog-like 2|DIS3-like exonuclease 2|family with sequence similarity 6, member A
|
| Swissprots |
Q69YG5 Q5XKH0 Q53S79 Q7Z4T6 Q6AW99 Q8IYB7 Q8N9K9 Q580W6
|
| Accessions |
AAX82031 AAY24086 EAW70988 Q8IYB7 AA781347 AF443854 AAP97321 AK090419 BAC03400 AK094293 BAC04324 AK295363 BAG58327 AL834174 CAH10694 AW589919 BC026166 AAH26166 BC030113 BC036113 AAH36113 BG746662 BM128478 BX648325 CAH10545 DA058505 EU176261 ABW03712 EU176572 ABW03373 NM_001257281 NP_001244210 NM_001257282 NP_001244211 NM_152383 NP_689596 NR_046476 NR_046477
|
| Function |
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:24141620}. Cytoplasm, P-body.
|