DIS3L2

Gene Symbol DIS3L2
Entrez Gene 129563
Alt Symbol FAM6A, PRLMNS, hDIS3L2
Species Human
Gene Type protein-coding
Description DIS3 like 3'-5' exoribonuclease 2
Other Description DIS3 mitotic control homolog-like 2|DIS3-like exonuclease 2|family with sequence similarity 6, member A
Swissprots Q69YG5 Q5XKH0 Q53S79 Q7Z4T6 Q6AW99 Q8IYB7 Q8N9K9 Q580W6
Accessions AAX82031 AAY24086 EAW70988 Q8IYB7 AA781347 AF443854 AAP97321 AK090419 BAC03400 AK094293 BAC04324 AK295363 BAG58327 AL834174 CAH10694 AW589919 BC026166 AAH26166 BC030113 BC036113 AAH36113 BG746662 BM128478 BX648325 CAH10545 DA058505 EU176261 ABW03712 EU176572 ABW03373 NM_001257281 NP_001244210 NM_001257282 NP_001244211 NM_152383 NP_689596 NR_046476 NR_046477
Function 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:24141620}. Cytoplasm, P-body.

DIS3L2 CRISPR/Cas9 KO Plasmid (h) - sc-405372 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 HDR Plasmid (h) - sc-405372-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 Double Nickase Plasmid (h) - sc-405372-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 Double Nickase Plasmid (h2) - sc-405372-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 CRISPR Activation Plasmid (h) - sc-405372-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 CRISPR Activation Plasmid (h2) - sc-405372-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 Lentiviral Activation Particles (h) - sc-405372-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 Lentiviral Activation Particles (h2) - sc-405372-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 siRNA (h) - sc-94849 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DIS3L2 shRNA Plasmid (h) - sc-94849-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DIS3L2 shRNA (h) Lentiviral Particles - sc-94849-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU158721 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7251 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7251 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04619 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04619

DIS3L2 siRNA (Human) - CRJ5004 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DIS3L2 RNAi - H00129563-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

DIS3L2 - MBS8205027 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DIS3L2 CRISPR/Cas9 KO Plasmid (h2) - sc-405372-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L2 HDR Plasmid (h2) - sc-405372-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human DIS3L2 (NM_152383.4) - SHH278261 from Creative biogene

Category siRNA
Species Reactivities Human

DIS3L2 shRNA Plasmid (Human) - CHJ5004 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DIS3L2 miRNA 3'UTR clone - MiUTR1H-02836 from Creative biogene

Species Reactivities Human
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