DIS3L2

Gene Symbol	DIS3L2
Entrez Gene	129563
Alt Symbol	FAM6A, PRLMNS, hDIS3L2
Species	Human
Gene Type	protein-coding
Description	DIS3 like 3'-5' exoribonuclease 2
Other Description	DIS3 mitotic control homolog-like 2|DIS3-like exonuclease 2|family with sequence similarity 6, member A
Swissprots	Q69YG5 Q5XKH0 Q53S79 Q7Z4T6 Q6AW99 Q8IYB7 Q8N9K9 Q580W6
Accessions	AAX82031 AAY24086 EAW70988 Q8IYB7 AA781347 AF443854 AAP97321 AK090419 BAC03400 AK094293 BAC04324 AK295363 BAG58327 AL834174 CAH10694 AW589919 BC026166 AAH26166 BC030113 BC036113 AAH36113 BG746662 BM128478 BX648325 CAH10545 DA058505 EU176261 ABW03712 EU176572 ABW03373 NM_001257281 NP_001244210 NM_001257282 NP_001244211 NM_152383 NP_689596 NR_046476 NR_046477
Function	3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:24141620}. Cytoplasm, P-body.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DIS3L2 Antibody Blocking Peptide - LS-E15113 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DIS3L2 Antibody Blocking Peptide - LS-E15114 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DIS3L2 Protein - H00129563-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DIS3-like exonuclease 2 - H00129563-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DIS3-like exonuclease 2 - H00129563-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DIS3L2 fusion protein - Ag22963 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DIS3L2, His-tagged - DIS3L2-28352TH from Creative Biomart Category Protein Source E. coli

Recombinant Human DIS3-like exonuclease 2(DIS3L2) ,partial - CSB-YP818258HU CSB-EP818258HU CSB-BP818258HU CSB-MP818258HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DIS3-like exonuclease 2 - TP305512 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DIS3L2 Recombinant Protein Antigen - NBP2-38264PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DIS3L2 Recombinant Protein Antigen - NBP1-84740PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DIS3L2 Peptide, Human - M34GP04321H from Creative Peptides Category Peptide Source Synthetic. Species Human

DIS3-like exonuclease 2 (DIS3L2), partial, Recombinant Protein - MBS1360492 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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