| Gene Symbol |
SMEK2
|
| Entrez Gene |
57223
|
| Alt Symbol |
FLFL2, PP4R3B, PSY2, smk1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMEK homolog 2, suppressor of mek1 (Dictyostelium)
|
| Other Description |
serine/threonine-protein phosphatase 4 regulatory subunit 3B
|
| Swissprots |
Q9P2G0 Q9BRK2 Q9H913 Q9BQJ0 Q6P9B0 Q5MIZ7 Q86XB8
|
| Accessions |
AAY24270 EAX00090 EAX00091 EAX00092 EAX00093 EAX00094 EAX00095 EAX00096 Q5MIZ7 AB037808 BAA92625 AK023148 BAB14430 AK026437 AK056036 AK056503 AK098321 AK296481 BAG59121 AL122106 AL136556 CAB66491 AY825268 AAV97750 AY825269 AAV97751 BC006215 AAH06215 BC032531 BC045714 AAH45714 BC060855 AAH60855 BE535214 DA392286 DB261776 XM_005264442 XP_005264499 XM_005264444 XP_005264501 XM_005264445 XP_005264502 XM_005264446 XP_005264503 XM_005264447 XP_005264504 XM_005264448 XP_005264505 XM_011533002 XP_011531304 NM_001122964 NP_001116436 NM_001282850 NP_001269779 NM_020463 NP_065196
|
| Function |
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18487071}. Nucleus {ECO:0000269|PubMed:18487071}. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions.
|
| Tissue Specificity |
Moderately expressed in tissues and specific brain regions examined. {ECO:0000269|PubMed:10718198}.
|
| Top Pathways |
Glucagon signaling pathway
|
![Western Blot: SMEK2 Overexpression Lysate (Adult Normal) [NBP2-06643] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMEK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8605_SMEK2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06643-img0001.jpg)