| Gene Symbol |
MAPK10
|
| Entrez Gene |
5602
|
| Alt Symbol |
JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase 10
|
| Other Description |
JNK3 alpha protein kinase|MAP kinase 10|MAP kinase p49 3F12|MAPK 10|c-Jun N-terminal kinase 3|stress activated protein kinase beta|stress-activated protein kinase 1b|stress-activated protein kinase JNK3
|
| Swissprots |
A6NG28 B3KQ94 Q15707 A6NFS3 Q49AP1 P53779
|
| Accessions |
CAC09126 CAP12256 CAP12257 CAP12259 EAX05962 EAX05963 P53779 AF052141 AK022161 AK057723 BAG51956 AK091104 BAG52284 AK124791 BAG54096 AK225974 AK294125 BAH11677 AK307129 BC022492 BC035057 AAH35057 BC051731 AAH51731 BC065516 AAH65516 BI549234 DA192997 HG497056 U07620 AAC50101 U34819 AAC50604 U34820 AAC50605 XM_005263129 XP_005263186 XM_005263130 XP_005263187 XM_005263131 XP_005263188 XM_005263135 XP_005263192 XM_005263136 XP_005263193 XM_006714268 XP_006714331 XM_006714269 XP_006714332 XM_006714271 XP_006714334 XM_006714272 XP_006714335 XM_011532117 XP_011530419 XM_011532118 XP_011530420 XM_011532119 XP_011530421 XM_011532120 XP_011530422 XM_011532121 XP_011530423 XM_011532122 XP_011530424 XM_011532123 XP_011530425 NM_002753 NP_002744 NM_138980 NP_620446 NM_138981 NP_620447 NM_138982 NP_620448
|
| Function |
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a rol
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16737965}. Membrane {ECO:0000269|PubMed:16737965}; Lipid-anchor {ECO:0000269|PubMed:16737965}. Nucleus {ECO:0000269|PubMed:16737965}. Mitochondrion {ECO:0000269|PubMed:16737965}. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
|
| Top Pathways |
Wnt signaling pathway, Herpes simplex infection, Dopaminergic synapse, Choline metabolism in cancer, cAMP signaling pathway
|