MAPK10

Gene Symbol	MAPK10
Entrez Gene	5602
Alt Symbol	JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 10
Other Description	JNK3 alpha protein kinase|MAP kinase 10|MAP kinase p49 3F12|MAPK 10|c-Jun N-terminal kinase 3|stress activated protein kinase beta|stress-activated protein kinase 1b|stress-activated protein kinase JNK3
Swissprots	A6NG28 B3KQ94 Q15707 A6NFS3 Q49AP1 P53779
Accessions	CAC09126 CAP12256 CAP12257 CAP12259 EAX05962 EAX05963 P53779 AF052141 AK022161 AK057723 BAG51956 AK091104 BAG52284 AK124791 BAG54096 AK225974 AK294125 BAH11677 AK307129 BC022492 BC035057 AAH35057 BC051731 AAH51731 BC065516 AAH65516 BI549234 DA192997 HG497056 U07620 AAC50101 U34819 AAC50604 U34820 AAC50605 XM_005263129 XP_005263186 XM_005263130 XP_005263187 XM_005263131 XP_005263188 XM_005263135 XP_005263192 XM_005263136 XP_005263193 XM_006714268 XP_006714331 XM_006714269 XP_006714332 XM_006714271 XP_006714334 XM_006714272 XP_006714335 XM_011532117 XP_011530419 XM_011532118 XP_011530420 XM_011532119 XP_011530421 XM_011532120 XP_011530422 XM_011532121 XP_011530423 XM_011532122 XP_011530424 XM_011532123 XP_011530425 NM_002753 NP_002744 NM_138980 NP_620446 NM_138981 NP_620447 NM_138982 NP_620448
Function	Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a rol
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16737965}. Membrane {ECO:0000269|PubMed:16737965}; Lipid-anchor {ECO:0000269|PubMed:16737965}. Nucleus {ECO:0000269|PubMed:16737965}. Mitochondrion {ECO:0000269|PubMed:16737965}. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). {ECO:0000250}.
Tissue Specificity	Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
Top Pathways	Wnt signaling pathway, Herpes simplex infection, Dopaminergic synapse, Choline metabolism in cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAPK10 gene - orb91441 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

MAPK10 - MBS1278868 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC065516

MAPK10 - MBS1270966 from MyBioSource Species Human Accession BC051731

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10626-M from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10626-ANG from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10626-NF from Sino Biological Species Human

Human MAPK10 transcript variant 1 Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10626-M-N from Sino Biological Species Human Accession NM_002753.2

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10626-NM from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10626-CY from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10626-CF from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10626-CM from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10626-NY from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10626-CH from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10626-M-F from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10626-ACR from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10626-ANR from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10626-ACG from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10626-UT from Sino Biological Species Human

Human MAPK10/JNK3 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10626-NH from Sino Biological Species Human

Human MAPK10 ORF Clone (BC065516) - CDCS410940 from Creative biogene Species Human Accession P53779

Human MAPK10 ORF Clone (BC051731) - CDCS410941 from Creative biogene Species Human Accession P53779

Human MAPK10 ORF clone (NM_002753.2) - CDCB157506 from Creative biogene Species Human

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