Gene Symbol | NMRK2 |
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Entrez Gene | 27231 |
Alt Symbol | ITGB1BP3, MIBP, NRK2 |
Species | Human |
Gene Type | protein-coding |
Description | nicotinamide riboside kinase 2 |
Other Description | NRK 2|RNK 2|integrin beta-1-binding protein 3|muscle-specific beta 1 integrin binding protein|nicotinic acid riboside kinase 2|nmR-K 2|ribosylnicotinamide kinase 2|ribosylnicotinic acid kinase 2 |
Swissprots | Q9NZK3 Q52M81 B7ZKR3 Q9NPI5 |
Accessions | CAM12701 EAW69277 EAW69278 EAW69279 Q9NPI5 AF190819 AAF26711 AK001663 BAA91820 AK022514 BAB14071 AL365377 CAB96949 AY611481 AAT11929 BC093637 AAH93637 BC101575 AAI01576 BC143329 AAI43330 BM669267 BM717225 XM_006722725 XP_006722788 XM_006722726 XP_006722789 NM_014446 NM_001289117 NP_001276046 NM_170678 NP_733778 NR_110316 |
Function | Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. {ECO:0000269|PubMed:10613898, ECO:0000269|PubMed:15137942}. |
Tissue Specificity | Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta. {ECO:0000269|PubMed:10613898}. |
Top Pathways | Nicotinate and nicotinamide metabolism |
Human ITGB1BP3 full length protein - ab131678 from Abcam
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MIBP / ITGB1BP3 Antibody Blocking Peptide - LS-E7099 from LifeSpan Bioscience
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MIBP / ITGB1BP3 Antibody Blocking Peptide - LS-E15729 from LifeSpan Bioscience
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ITGB1BP3 Recombinant Protein - H00027231-P01 from Novus Biologicals
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Recombinant Human ITGB1BP3 Protein - NBP2-23286 from Novus Biologicals
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ITGB1BP3-Antibody-N-term-Blocking-Peptide - BP2791a from Abgent, a WuXi AppTec company
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Human ITGB1BP3 protein - orb168679 from Biorbyt
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ITGB1BP3 Blocking Peptide - 33R-10154 from Fitzgerald
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ITGB1BP3 protein (His tag) - 80R-2414 from Fitzgerald
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ITGB1BP3 / NRK2 (1-230, His-tag) - AR50494PU-N from Acris Antibodies
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ITGB1BP3 / NRK2 (1-230, His-tag) - AR50494PU-S from Acris Antibodies
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ITGB1BP3 / NRK2 - H00027231-P01-10 from Acris Antibodies
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ITGB1BP3 / NRK2 - H00027231-P01-25 from Acris Antibodies
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ITGB1BP3, 1-230aa, Human, His tag, E.coli - 01-P1670 from ARP American Research Products
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ITGB1BP3 Human - PRPS-1184 from NeoScientific
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Recombinant Human ITGB1BP3 Protein - BP002678-PRO-1177 from Syd Labs
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ITGB1BP3, 1-230aa, Recombinant Protein - GWB-P0368D from Genway Biotech
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ITGB1BP3 - PAT-80560-1 from Nordic BioSite
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ITGB1BP3 - PAT-80560-2 from Nordic BioSite
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Recombinant Human Nicotinamide riboside kinase 2(ITGB1BP3) - CSB-YP878845HU CSB-EP878845HU CSB-BP878845HU CSB-MP878845HU from Cusabio
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ITGB1BP3, 1-230aa, Human, His tag, E.coli - ATGP1670 from ATGen
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ITGB1BP3-Blocking-Peptide-Center - BP2791c from Abgent, a WuXi AppTec company
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NMRK2 Peptide, Human - M34GP10466H from Creative Peptides
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ITGB1BP3 fusion protein - Ag26295 from Proteintech Group
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Integrin Beta 1 Binding Protein 3, Recombinant Protein - MBS145012 from MyBioSource
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