Gene Symbol | NMRK2 |
---|---|
Entrez Gene | 27231 |
Alt Symbol | ITGB1BP3, MIBP, NRK2 |
Species | Human |
Gene Type | protein-coding |
Description | nicotinamide riboside kinase 2 |
Other Description | NRK 2|RNK 2|integrin beta-1-binding protein 3|muscle-specific beta 1 integrin binding protein|nicotinic acid riboside kinase 2|nmR-K 2|ribosylnicotinamide kinase 2|ribosylnicotinic acid kinase 2 |
Swissprots | Q9NZK3 Q52M81 B7ZKR3 Q9NPI5 |
Accessions | CAM12701 EAW69277 EAW69278 EAW69279 Q9NPI5 AF190819 AAF26711 AK001663 BAA91820 AK022514 BAB14071 AL365377 CAB96949 AY611481 AAT11929 BC093637 AAH93637 BC101575 AAI01576 BC143329 AAI43330 BM669267 BM717225 XM_006722725 XP_006722788 XM_006722726 XP_006722789 NM_014446 NM_001289117 NP_001276046 NM_170678 NP_733778 NR_110316 |
Function | Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. {ECO:0000269|PubMed:10613898, ECO:0000269|PubMed:15137942}. |
Tissue Specificity | Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta. {ECO:0000269|PubMed:10613898}. |
Top Pathways | Nicotinate and nicotinamide metabolism |
MIBP CRISPR/Cas9 KO Plasmid (h) - sc-407421 from Santa Cruz Biotechnology
|
||||||||
MIBP HDR Plasmid (h) - sc-407421-HDR from Santa Cruz Biotechnology
|
||||||||
MIBP Double Nickase Plasmid (h) - sc-407421-NIC from Santa Cruz Biotechnology
|
||||||||
MIBP Double Nickase Plasmid (h2) - sc-407421-NIC-2 from Santa Cruz Biotechnology
|
||||||||
MIBP CRISPR Activation Plasmid (h) - sc-407421-ACT from Santa Cruz Biotechnology
|
||||||||
MIBP CRISPR Activation Plasmid (h2) - sc-407421-ACT-2 from Santa Cruz Biotechnology
|
||||||||
MIBP Lentiviral Activation Particles (h) - sc-407421-LAC from Santa Cruz Biotechnology
|
||||||||
MIBP Lentiviral Activation Particles (h2) - sc-407421-LAC-2 from Santa Cruz Biotechnology
|
||||||||
MIBP siRNA (h) - sc-97715 from Santa Cruz Biotechnology
|
||||||||
MIBP shRNA Plasmid (h) - sc-97715-SH from Santa Cruz Biotechnology
|
||||||||
MIBP shRNA (h) Lentiviral Particles - sc-97715-V from Santa Cruz Biotechnology
|
||||||||
ITGB1BP3 RNAi - H00027231-R03 from Novus Biologicals
|
||||||||
ITGB1BP3 RNAi - H00027231-R04 from Novus Biologicals
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN10817 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10817 from Sigma-Aldrich
|
||||||||
NMRK2 siRNA (Human) - CRH9025 from Cohesion Biosciences
|
||||||||
shRNA set against Human ITGB1BP3 (NM_170678.2) - SHH321377 from Creative biogene
|
||||||||
shRNA set against Human ITGB1BP3(NM_170678.2) - SHL183546 from Creative biogene
|
||||||||
Human NMRK2 siRNA - orb269527 from Biorbyt
|
||||||||
NMRK2 shRNA Plasmid (Human) - CHH9025 from Cohesion Biosciences
|
||||||||
NMRK2 miRNA 3'UTR clone - MiUTR1H-05035 from Creative biogene
|