| Gene Symbol |
KIAA0319
|
| Entrez Gene |
9856
|
| Alt Symbol |
DYLX2, DYX2, NMIG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KIAA0319
|
| Other Description |
dyslexia susceptibility 2|dyslexia-associated protein KIAA0319|neuronal migration
|
| Swissprots |
Q5VV43 B2RTU7 F5H123 Q9Y4G7 B4DHA7 B7ZML3 Q9UJC8 B4DK75 A7MD37
|
| Accessions |
CCQ43461 EAW55455 EAW55456 EAW55457 Q5VV43 AB002317 BAA20777 AF086065 AK295008 BAG58068 AK296310 BAG59008 AK296426 BAG59087 AK307503 AK310289 AL044313 BC140821 AAI40822 BC144628 AAI44629 BC152460 AAI52461 BX646625 DA316925 DA808234 XM_006715288 XP_006715351 XM_011515022 XP_011513324 XM_011515023 XP_011513325 XM_011515024 XP_011513326 XM_011515025 XP_011513327 XM_011515026 XP_011513328 XM_011515027 XP_011513329 NM_001168374 NP_001161846 NM_001168375 NP_001161847 NM_001168376 NP_001161848 NM_001168377 NP_001161849 NM_001252328 NP_001239257 NM_014809 NP_055624
|
| Function |
Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. {ECO:0000269|PubMed:19679544}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted.
|
| Tissue Specificity |
Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum. {ECO:0000269|PubMed:12834540, ECO:0000269|PubMed:17846832}.
|