Gene Symbol | KIAA0319 |
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Entrez Gene | 9856 |
Alt Symbol | DYLX2, DYX2, NMIG |
Species | Human |
Gene Type | protein-coding |
Description | KIAA0319 |
Other Description | dyslexia susceptibility 2|dyslexia-associated protein KIAA0319|neuronal migration |
Swissprots | Q5VV43 B2RTU7 F5H123 Q9Y4G7 B4DHA7 B7ZML3 Q9UJC8 B4DK75 A7MD37 |
Accessions | CCQ43461 EAW55455 EAW55456 EAW55457 Q5VV43 AB002317 BAA20777 AF086065 AK295008 BAG58068 AK296310 BAG59008 AK296426 BAG59087 AK307503 AK310289 AL044313 BC140821 AAI40822 BC144628 AAI44629 BC152460 AAI52461 BX646625 DA316925 DA808234 XM_006715288 XP_006715351 XM_011515022 XP_011513324 XM_011515023 XP_011513325 XM_011515024 XP_011513326 XM_011515025 XP_011513327 XM_011515026 XP_011513328 XM_011515027 XP_011513329 NM_001168374 NP_001161846 NM_001168375 NP_001161847 NM_001168376 NP_001161848 NM_001168377 NP_001161849 NM_001252328 NP_001239257 NM_014809 NP_055624 |
Function | Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. {ECO:0000269|PubMed:19679544}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted. |
Tissue Specificity | Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum. {ECO:0000269|PubMed:12834540, ECO:0000269|PubMed:17846832}. |
DYX2 CRISPR/Cas9 KO Plasmid (h) - sc-411367 from Santa Cruz Biotechnology
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DYX2 HDR Plasmid (h) - sc-411367-HDR from Santa Cruz Biotechnology
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DYX2 Double Nickase Plasmid (h) - sc-411367-NIC from Santa Cruz Biotechnology
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DYX2 Double Nickase Plasmid (h2) - sc-411367-NIC-2 from Santa Cruz Biotechnology
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DYX2 CRISPR Activation Plasmid (h) - sc-411367-ACT from Santa Cruz Biotechnology
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DYX2 CRISPR Activation Plasmid (h2) - sc-411367-ACT-2 from Santa Cruz Biotechnology
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DYX2 Lentiviral Activation Particles (h) - sc-411367-LAC from Santa Cruz Biotechnology
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DYX2 Lentiviral Activation Particles (h2) - sc-411367-LAC-2 from Santa Cruz Biotechnology
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DYX2 siRNA (h) - sc-95513 from Santa Cruz Biotechnology
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DYX2 shRNA Plasmid (h) - sc-95513-SH from Santa Cruz Biotechnology
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DYX2 shRNA (h) Lentiviral Particles - sc-95513-V from Santa Cruz Biotechnology
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KIAA0319 RNAi - H00009856-R01 from Novus Biologicals
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MISSION® esiRNA - EHU129711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11071 from Sigma-Aldrich
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KIAA0319 siRNA (Human) - CRH6606 from Cohesion Biosciences
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shRNA set against Human KIAA0319 (NM_014809.3) - SHH324535 from Creative biogene
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Human KIAA0319 siRNA - orb267108 from Biorbyt
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KIAA0319 shRNA Plasmid (Human) - CHH6606 from Cohesion Biosciences
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KIAA0319 miRNA 3'UTR clone - MiUTR1H-05210 from Creative biogene
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