| Gene Symbol |
GATAD2B
|
| Entrez Gene |
57459
|
| Alt Symbol |
MRD18, P66beta, p68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GATA zinc finger domain containing 2B
|
| Other Description |
GATA zinc finger domain-containing protein 2B|p66/p68|transcription repressor p66 beta component of the MeCP1 complex|transcriptional repressor p66-beta
|
| Swissprots |
Q7LG68 Q5VUR2 Q8WXI9 D3DUZ2 Q9ULS0
|
| Accessions |
EAW53270 Q8WXI9 AB032976 BAA86464 AF411836 AAL39080 AI701819 AK094665 BAG52906 BC069419 AAH69419 BC112052 AAI12053 BC112080 AAI12081 DA161156 EU446499 ABZ92028 XM_005245364 XP_005245421 XM_006711469 XP_006711532 XM_011509808 XP_011508110 NM_020699 NP_065750
|
| Function |
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}. Note=Speckled nuclear localization requires both CR1 and CR2 regions.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12183469}.
|
![Western Blot: p66 beta Overexpression Lysate (Adult Normal) [NBL1-10987] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for p66 beta.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4888_p66%2520beta%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10987-img0002.jpg)