Gene Symbol | GATAD2B |
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Entrez Gene | 57459 |
Alt Symbol | MRD18, P66beta, p68 |
Species | Human |
Gene Type | protein-coding |
Description | GATA zinc finger domain containing 2B |
Other Description | GATA zinc finger domain-containing protein 2B|p66/p68|transcription repressor p66 beta component of the MeCP1 complex|transcriptional repressor p66-beta |
Swissprots | Q7LG68 Q5VUR2 Q8WXI9 D3DUZ2 Q9ULS0 |
Accessions | EAW53270 Q8WXI9 AB032976 BAA86464 AF411836 AAL39080 AI701819 AK094665 BAG52906 BC069419 AAH69419 BC112052 AAI12053 BC112080 AAI12081 DA161156 EU446499 ABZ92028 XM_005245364 XP_005245421 XM_006711469 XP_006711532 XM_011509808 XP_011508110 NM_020699 NP_065750 |
Function | Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}. |
Subcellular Location | Nucleus speckle {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}. Note=Speckled nuclear localization requires both CR1 and CR2 regions. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12183469}. |
GATAD2B CRISPR/Cas9 KO Plasmid (h) - sc-412799 from Santa Cruz Biotechnology
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GATAD2B HDR Plasmid (h) - sc-412799-HDR from Santa Cruz Biotechnology
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GATAD2B Double Nickase Plasmid (h) - sc-412799-NIC from Santa Cruz Biotechnology
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GATAD2B Double Nickase Plasmid (h2) - sc-412799-NIC-2 from Santa Cruz Biotechnology
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GATAD2B CRISPR Activation Plasmid (h) - sc-412799-ACT from Santa Cruz Biotechnology
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GATAD2B CRISPR Activation Plasmid (h2) - sc-412799-ACT-2 from Santa Cruz Biotechnology
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GATAD2B Lentiviral Activation Particles (h) - sc-412799-LAC from Santa Cruz Biotechnology
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GATAD2B Lentiviral Activation Particles (h2) - sc-412799-LAC-2 from Santa Cruz Biotechnology
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GATAD2B siRNA (h) - sc-88495 from Santa Cruz Biotechnology
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GATAD2B shRNA Plasmid (h) - sc-88495-SH from Santa Cruz Biotechnology
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GATAD2B shRNA (h) Lentiviral Particles - sc-88495-V from Santa Cruz Biotechnology
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p66 beta RNAi - H00057459-R01 from Novus Biologicals
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MISSION® esiRNA - EHU143111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9154 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9154 from Sigma-Aldrich
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GATAD2B siRNA (Human) - CRJ1452 from Cohesion Biosciences
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GATAD2B - MBS8240772 from MyBioSource
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shRNA set against Human GATAD2B (NM_020699.2) - SHH299618 from Creative biogene
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shRNA set against Human GATAD2B(NM_020699.2) - SHH078473 from Creative biogene
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GATAD2B shRNA Plasmid (Human) - CHJ1452 from Cohesion Biosciences
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GATAD2B miRNA 3'UTR clone - MiUTR1H-03968 from Creative biogene
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