| Gene Symbol |
HIPK2
|
| Entrez Gene |
28996
|
| Alt Symbol |
PRO0593
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
homeodomain interacting protein kinase 2
|
| Other Description |
hHIPk2|homeodomain-interacting protein kinase 2
|
| Swissprots |
Q9H2Y1 Q75MR7 Q9H2X6 Q8WWI4
|
| Accessions |
AAS00368 CAI38625 CAI40576 EAL24035 EAW83925 EAW83926 EAW83927 EAW83928 EAW83929 Q9H2X6 AF055019 AF111850 AAF16689 AF207702 AAG35710 AF208291 AAG41236 AF326592 AAL37371 AI580907 AK074291 AL833223 BC041926 BC043184 BC043652 BC045719 BC168360 AAI68360 BX647377 CK818532 CN413736 XM_006715935 XP_006715998 XM_011516077 XP_011514379 XM_011516078 XP_011514380 XM_011516079 XP_011514381 XM_011516080 XP_011514382 XM_011516081 XP_011514383 NM_001113239 NP_001106710 NM_022740 NP_073577
|
| Function |
Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signa
|
| Subcellular Location |
Nucleus, PML body. Cytoplasm. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts are cytoplasmic.
|
| Tissue Specificity |
Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors. {ECO:0000269|PubMed:11267674, ECO:0000269|PubMed:11798164}.
|
![Western Blot: HIPK2 Overexpression Lysate (Adult Normal) [NBP2-06409] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HIPK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/794_HIPK2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06409-img0001.jpg)