HIPK2

Gene Symbol	HIPK2
Entrez Gene	28996
Alt Symbol	PRO0593
Species	Human
Gene Type	protein-coding
Description	homeodomain interacting protein kinase 2
Other Description	hHIPk2|homeodomain-interacting protein kinase 2
Swissprots	Q9H2Y1 Q75MR7 Q9H2X6 Q8WWI4
Accessions	AAS00368 CAI38625 CAI40576 EAL24035 EAW83925 EAW83926 EAW83927 EAW83928 EAW83929 Q9H2X6 AF055019 AF111850 AAF16689 AF207702 AAG35710 AF208291 AAG41236 AF326592 AAL37371 AI580907 AK074291 AL833223 BC041926 BC043184 BC043652 BC045719 BC168360 AAI68360 BX647377 CK818532 CN413736 XM_006715935 XP_006715998 XM_011516077 XP_011514379 XM_011516078 XP_011514380 XM_011516079 XP_011514381 XM_011516080 XP_011514382 XM_011516081 XP_011514383 NM_001113239 NP_001106710 NM_022740 NP_073577
Function	Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signa
Subcellular Location	Nucleus, PML body. Cytoplasm. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts are cytoplasmic.
Tissue Specificity	Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors. {ECO:0000269|PubMed:11267674, ECO:0000269|PubMed:11798164}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse HIPK2 protein fragment - ab125553 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Mouse

Human HIPK2 peptide - ab111675 from Abcam Category Peptide Species Human

Human HIPK2 protein fragment - ab153300 from Abcam Category Protein Source Wheat germ Species Human

HIPK2 Antibody Blocking Peptide - LS-E7441 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIPK2 Antibody Blocking Peptide - LS-E11438 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIPK2 Antibody Blocking Peptide - LS-E9035 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HIPK2 Protein - H00028996-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Phospho-HIPK2Y361-Antibody-Blocking-peptide - BP3616a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

HIPK2-Antibody-Y361-Blocking-Peptide - BP7539f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIPK2 peptide - orb218499 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

HIPK2 Blocking Peptide - abx063830 from Abbexa Category Peptide Species Human, Mouse, Rat

HIPK2 - H00028996-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HIPK2 - H00028996-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HIPK2 - P5561 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Recombinant Homeodomain Interacting Protein Kinase 2 (HIPK2) - RPF477Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

HIPK2 Protein, active, 250 µg - 14-623M from EMD Millipore Category Protein Prices $2,441.00 Sizes 250 µg also available in 10 μg size . (cat#14-623) and in bulk (cat#14-623-K) Source baculovirus in Sf21 insect cells

HIPK2 Blocking Peptide - CBP2636 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

HIPK2 Peptide - BS60320P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Homeodomain-interacting protein kinase 2(HIPK2) ,partial - CSB-YP867138HU CSB-EP867138HU CSB-BP867138HU CSB-MP867138HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HIPK2 (transcript variant 1) - TP320278 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HIPK2 Recombinant Protein Antigen - NBP1-89462PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HIPK2 Protein, active, 10 µg - 14-623 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg Source baculovirus in Sf21 insect cells

HIPK2-Antibody-C-term-D1050-Blocking-Peptide - BP7539d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIPK2-Antibody-N-term-T104-Blocking-Peptide - BP7539c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIPK2-Antibody-C-term-Blocking-Peptide - BP7539b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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