| Gene Symbol |
PIK3C2B
|
| Entrez Gene |
5287
|
| Alt Symbol |
C2-PI3K
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
|
| Other Description |
PI3K-C2-beta|PI3K-C2beta|PTDINS-3-kinase C2 beta|phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide|phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta|phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta|phosphoinositide 3-kinase-C2-beta|phosphoinositide-3-kinase, class 2, beta polypeptide|ptdIns-3-kinase C2 subunit beta
|
| Swissprots |
Q5SW99 O00750 O95666
|
| Accessions |
ABY87552 AGC09602 EAW91513 EAW91514 O00750 AB210006 BAE06088 AK308153 BC094741 BC132876 AAI32877 BC136645 AAI36646 BC144342 AAI44343 CR749201 CAH18059 F17716 Y11312 CAA72168 Y13892 CAA74194 XM_005245257 XP_005245314 XM_005245258 XP_005245315 XM_011509630 XP_011507932 XM_011509631 XP_011507933 XM_011509632 XP_011507934 XM_011509633 XP_011507935 XR_241085 XR_241086 NM_002646 NP_002637
|
| Function |
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. {ECO:0000269|PubMed:10805725}.
|
| Subcellular Location |
Microsome {ECO:0000269|PubMed:14563213}. Cell membrane {ECO:0000269|PubMed:14563213}. Cytoplasm, cytosol {ECO:0000269|PubMed:14563213}. Nucleus {ECO:0000269|PubMed:14563213}. Endoplasmic reticulum {ECO:0000269|PubMed:14563213}. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
|
| Tissue Specificity |
Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9144573}.
|
| Top Pathways |
Inositol phosphate metabolism, Phosphatidylinositol signaling system
|