PIK3C2B

Gene Symbol	PIK3C2B
Entrez Gene	5287
Alt Symbol	C2-PI3K
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Other Description	PI3K-C2-beta|PI3K-C2beta|PTDINS-3-kinase C2 beta|phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide|phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta|phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta|phosphoinositide 3-kinase-C2-beta|phosphoinositide-3-kinase, class 2, beta polypeptide|ptdIns-3-kinase C2 subunit beta
Swissprots	Q5SW99 O00750 O95666
Accessions	ABY87552 AGC09602 EAW91513 EAW91514 O00750 AB210006 BAE06088 AK308153 BC094741 BC132876 AAI32877 BC136645 AAI36646 BC144342 AAI44343 CR749201 CAH18059 F17716 Y11312 CAA72168 Y13892 CAA74194 XM_005245257 XP_005245314 XM_005245258 XP_005245315 XM_011509630 XP_011507932 XM_011509631 XP_011507933 XM_011509632 XP_011507934 XM_011509633 XP_011507935 XR_241085 XR_241086 NM_002646 NP_002637
Function	Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. {ECO:0000269|PubMed:10805725}.
Subcellular Location	Microsome {ECO:0000269|PubMed:14563213}. Cell membrane {ECO:0000269|PubMed:14563213}. Cytoplasm, cytosol {ECO:0000269|PubMed:14563213}. Nucleus {ECO:0000269|PubMed:14563213}. Endoplasmic reticulum {ECO:0000269|PubMed:14563213}. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
Tissue Specificity	Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9144573}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PIK3C2B protein fragment - ab159125 from Abcam Category Protein Source Wheat germ Species Human

PIK3C2B Antibody Blocking Peptide - LS-E9424 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PI 3-Kinase C2 beta Protein - H00005287-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PI 3-Kinase C2 beta Peptide - P2984 from Novus Biologicals Category Peptide Species Human

PI3KC2B-Antibody-N-term-Blocking-Peptide - BP8011a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIK3C2B - H00005287-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIK3C2B - H00005287-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIK3C2B fusion protein - Ag20478 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PIK3C2B fusion protein - Ag20474 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PIK3C2B, GST-tagged - PIK3C2B-118H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human PIK3C2B, His-tagged - PIK3C2B-1716H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) - RPJ826Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

PI3K-C2β Protein, 250 µg - 14-907M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-907) and in bulk (cat# 14-907-K) Source Expressed by baculovirus in Sf21 insect cells

PIK3C2B protein-GST fusion - 009-001-S97 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

PIK3C2B protein-GST fusion - 009-001-S97S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing - CSB-YP017995HU CSB-EP017995HU CSB-BP017995HU CSB-MP017995HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PIK3C2B - TP318354 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B), partial, Recombinant Protein - MBS1233146 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Phosphoinositide 3 Kinase, Bovine, p110 alpha, p85 alpha, Recombinant Protein - MBS636613 from MyBioSource Category Protein Prices $420.00, $540.00 Sizes 1 µg, 2.5 µg Source Sf9 insect cells Species Bovine

Phosphoinositide 3 Kinase, Bovine, p85 alpha, Recombinant Protein - MBS636475 from MyBioSource Category Protein Prices $445.00, $585.00 Sizes 2 µg, 10 µg Source Leishmania tarentolae Species Bovine

Phosphoinositide 3-kinase p110g, Recombinant Protein - MBS142823 from MyBioSource Category Protein Prices $265.00, $455.00, $645.00 Sizes 1 µg, 5 µg, 10 µg Source Sf9 Insect Cells

PIK3C2B, Recombinant Protein - MBS515420 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

PI3K-C2β Protein, 10 µg - 14-907 from EMD Millipore Category Protein Prices $730.00 Sizes 10 µg also available in 250μg size as catalog # 14-907m - call for pricing and availability. Source Expressed by baculovirus in Sf21 insect cells

PI 3-Kinase C2 beta Recombinant Protein Antigen - NBP1-86795PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Phospho-HUMAN-PIK3C2BY228-Blocking-Peptide - BP3903b from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg Species Human

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