| Gene Symbol |
RAB20
|
| Entrez Gene |
55647
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB20, member RAS oncogene family
|
| Other Description |
ras-related protein Rab-20
|
| Swissprots |
Q5T9X5 Q9NX57 Q9NX49
|
| Accessions |
EAX09113 Q9NX57 AJ272065 CAC81247 AK000436 BAA91163 AK000446 BAA91171 BC026025 AAH26025 BU528103 DQ892145 ABM83071 DQ895340 ABM86266 HY010547 NM_017817 NP_060287
|
| Function |
Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. {ECO:0000269|PubMed:21255211}.
|
| Subcellular Location |
Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250}.
|
| Tissue Specificity |
Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level). {ECO:0000269|PubMed:16613320}.
|