Gene Symbol | RAB20 |
---|---|
Entrez Gene | 55647 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | RAB20, member RAS oncogene family |
Other Description | ras-related protein Rab-20 |
Swissprots | Q5T9X5 Q9NX57 Q9NX49 |
Accessions | EAX09113 Q9NX57 AJ272065 CAC81247 AK000436 BAA91163 AK000446 BAA91171 BC026025 AAH26025 BU528103 DQ892145 ABM83071 DQ895340 ABM86266 HY010547 NM_017817 NP_060287 |
Function | Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. {ECO:0000269|PubMed:21255211}. |
Subcellular Location | Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250}. |
Tissue Specificity | Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level). {ECO:0000269|PubMed:16613320}. |