| Gene Symbol |
MAP1LC3A
|
| Entrez Gene |
84557
|
| Alt Symbol |
ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule-associated protein 1 light chain 3 alpha
|
| Other Description |
MAP1 light chain 3-like protein 1|MAP1A/1B light chain 3 A|MAP1A/MAP1B LC3 A|MAP1A/MAP1B light chain 3 A|autophagy-related ubiquitin-like modifier LC3 A|microtubule-associated proteins 1A/1B light chain 3|microtubule-associated proteins 1A/1B light chain 3A
|
| Swissprots |
Q9BXW5 E1P5P5 E1P5P4 Q9H492
|
| Accessions |
EAW76263 EAW76264 EAW76265 EAW76266 Q9H492 AF276658 AAK35151 AL833855 CAD38714 AM392590 CAL37468 BC015810 AAH15810 BM740344 BM919877 BP212418 BT007452 AAP36120 DQ893641 ABM84567 DQ895536 ABM86462 EL954540 H18312 XM_011529083 XP_011527385 XM_011529084 XP_011527386 XM_011529085 XP_011527387 NM_032514 NP_115903 NM_181509 NP_852610
|
| Function |
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269|PubMed:20713600}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes.
|
| Tissue Specificity |
Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:12740394}.
|
![Western Blot: LC3/MAP1LC3A Overexpression Lysate (Denatured) [H00084557-T01] - Lane 1: MAP1LC3A transfected lysate (13.31 KDa) Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/27564_LC3-MAP1LC3A-Overexpression-Lysate-(Denatured)-Western-Blot-H00084557-T01-img0002.jpg)
![Western Blot: LC3 Overexpression Lysate (Adult Normal) [NBL1-12843] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LC3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13874_LC3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-12843-img0002.jpg)