Gene Symbol | MAP1LC3A |
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Entrez Gene | 84557 |
Alt Symbol | ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3 |
Species | Human |
Gene Type | protein-coding |
Description | microtubule-associated protein 1 light chain 3 alpha |
Other Description | MAP1 light chain 3-like protein 1|MAP1A/1B light chain 3 A|MAP1A/MAP1B LC3 A|MAP1A/MAP1B light chain 3 A|autophagy-related ubiquitin-like modifier LC3 A|microtubule-associated proteins 1A/1B light chain 3|microtubule-associated proteins 1A/1B light chain 3A |
Swissprots | Q9BXW5 E1P5P5 E1P5P4 Q9H492 |
Accessions | EAW76263 EAW76264 EAW76265 EAW76266 Q9H492 AF276658 AAK35151 AL833855 CAD38714 AM392590 CAL37468 BC015810 AAH15810 BM740344 BM919877 BP212418 BT007452 AAP36120 DQ893641 ABM84567 DQ895536 ABM86462 EL954540 H18312 XM_011529083 XP_011527385 XM_011529084 XP_011527386 XM_011529085 XP_011527387 NM_032514 NP_115903 NM_181509 NP_852610 |
Function | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269|PubMed:20713600}. |
Subcellular Location | Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. |
Tissue Specificity | Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:12740394}. |
Human MAP1LC3A full length protein - ab98119 from Abcam
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Human MAP1LC3A full length protein - ab171754 from Abcam
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Human MAP1LC3A full length protein - ab190045 from Abcam
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Human MAP1LC3A full length protein - ab190437 from Abcam
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Human MAP1LC3A peptide - ab99367 from Abcam
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Human MAP1LC3A protein fragment - ab92050 from Abcam
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Rat MAP1LC3A peptide - ab64589 from Abcam
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Rat MAP1LC3A peptide - ab64590 from Abcam
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MAP1LC3A / LC3A Antibody Blocking Peptide - LS-E5531 from LifeSpan Bioscience
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MAP1LC3A / LC3A Antibody Blocking Peptide - LS-E5498 from LifeSpan Bioscience
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MAP1LC3A / LC3A Antibody Blocking Peptide - LS-E5499 from LifeSpan Bioscience
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MAP1LC3A / LC3A Antibody Blocking Peptide - LS-E18485 from LifeSpan Bioscience
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MAP1LC3A / LC3A Antibody Blocking Peptide - LS-E7337 from LifeSpan Bioscience
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MAP1LC3A / LC3A Antibody Blocking Peptide - LS-E21557 from LifeSpan Bioscience
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Recombinant Human LC3A Protein - H00084557-P01 from Novus Biologicals
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Recombinant Human LC3A Protein - NBP1-45308 from Novus Biologicals
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LC3/MAP1LC3A Partial Recombinant Protein - H00084557-Q01 from Novus Biologicals
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LC3/MAP1LC3A Peptide - P1454 from Novus Biologicals
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Cleaved-LC3A-Antibody-Blocking-peptide - BP1805a from Abgent, a WuXi AppTec company
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LC3-Antibody-APG8a-D106-Blocking-Peptide - BP1801d from Abgent, a WuXi AppTec company
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LC3-Antibody-APG8a-N-term-Blocking-Peptide - BP1801a from Abgent, a WuXi AppTec company
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Phospho-LC3CS12-Antibody-Blocking-peptide - BP3301a from Abgent, a WuXi AppTec company
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LC3 Protein - GTX118992-pro from GeneTex
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Recombinant Human HA-LC3/MAP1LC3A/Apg8p3 AMC, CF - UL-450-025 from R&D Systems
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Recombinant Human LC3/MAP1LC3A/Apg8p3 Agarose, CF - UL-435-500 from R&D Systems
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