| Gene Symbol |
CLIP1
|
| Entrez Gene |
6249
|
| Alt Symbol |
CLIP, CLIP-170, CLIP170, CYLN1, RSN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CAP-GLY domain containing linker protein 1
|
| Other Description |
CAP-Gly domain-containing linker protein 1|cytoplasmic linker protein 1|cytoplasmic linker protein 170 alpha-2|cytoplasmic linker protein CLIP-170|restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
|
| Swissprots |
Q29RG0 Q17RS4 A0AVD3 P30622
|
| Accessions |
EAW98320 EAW98321 EAW98322 EAW98323 P30622 AB209115 BAD92352 AF045652 AAC03549 AF045653 AAC03550 AK123769 AK126990 BAG54417 AY563000 AAS75590 BC039081 BC047895 AAH47895 BC062543 AAH62543 BC114213 AAI14214 BC117209 AAI17210 BC126305 AAI26306 BM998166 CB305431 M97501 AAA35693 X64838 CAA46050 XM_005253593 XP_005253650 XM_006719552 XP_006719615 NM_001247997 NP_001234926 NM_002956 NP_002947 NM_198240 NP_937883
|
| Function |
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles.
|
| Tissue Specificity |
Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:1600942}.
|