Gene Symbol | CLIP1 |
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Entrez Gene | 6249 |
Alt Symbol | CLIP, CLIP-170, CLIP170, CYLN1, RSN |
Species | Human |
Gene Type | protein-coding |
Description | CAP-GLY domain containing linker protein 1 |
Other Description | CAP-Gly domain-containing linker protein 1|cytoplasmic linker protein 1|cytoplasmic linker protein 170 alpha-2|cytoplasmic linker protein CLIP-170|restin (Reed-Steinberg cell-expressed intermediate filament-associated protein) |
Swissprots | Q29RG0 Q17RS4 A0AVD3 P30622 |
Accessions | EAW98320 EAW98321 EAW98322 EAW98323 P30622 AB209115 BAD92352 AF045652 AAC03549 AF045653 AAC03550 AK123769 AK126990 BAG54417 AY563000 AAS75590 BC039081 BC047895 AAH47895 BC062543 AAH62543 BC114213 AAI14214 BC117209 AAI17210 BC126305 AAI26306 BM998166 CB305431 M97501 AAA35693 X64838 CAA46050 XM_005253593 XP_005253650 XM_006719552 XP_006719615 NM_001247997 NP_001234926 NM_002956 NP_002947 NM_198240 NP_937883 |
Function | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles. |
Tissue Specificity | Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:1600942}. |
CLIP1 / CLIP-170 Antibody Blocking Peptide - LS-E22551 from LifeSpan Bioscience
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CLIP1 / CLIP-170 Antibody Blocking Peptide - LS-E27124 from LifeSpan Bioscience
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CLIP1 / CLIP-170 Antibody Blocking Peptide - LS-E9869 from LifeSpan Bioscience
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CLIP1 / CLIP-170 Antibody Blocking Peptide - LS-E30523 from LifeSpan Bioscience
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CLIP170 Blocking Peptide - NBP1-76921PEP from Novus Biologicals
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CLIP1-Antibody-N-term-Blocking-Peptide - BP8950a from Abgent, a WuXi AppTec company
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CLIP170 Peptide - GTX85030-PEP from GeneTex
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CLIP170 blocking peptide - GTX88382-PEP from GeneTex
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CLIP1 Blocking Peptide - 33R-5364 from Fitzgerald
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CLIP1 Blocking Peptide - abx063235 from Abbexa
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CLIP170 Peptide - AC21-1944-P from Abcore
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CLIP1 / Restin Control Peptide - AP30237CP-N from Acris Antibodies
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CLIP1 Peptide - 42-107P from ProSci
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CLIP170 Peptide - 4659P from ProSci
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CLIP1 fusion protein - ag20811 from Proteintech Group
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CLIP1 Blocking Peptide - CBP2041 from Cohesion Biosciences
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CLIP-170 (K1332) Peptide - BS3275P from Bioworld Technology
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Recombinant Human CAP-Gly domain-containing linker protein 1(CLIP1) ,partial - CSB-YP005553HU CSB-EP005553HU CSB-BP005553HU CSB-MP005553HU from Cusabio
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CLIP1 Protein - abx163917 from Abbexa
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CAP-Gly domain-containing linker protein 1 (CLIP1), partial, Recombinant Protein - MBS953571 from MyBioSource
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Restin/CLIP1, Peptide - MBS426905 from MyBioSource
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CLIP170 Recombinant Protein Antigen - NBP1-85568PEP from Novus Biologicals
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CLIP1 Peptide, Human - M34GP03288H from Creative Peptides
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CLIP1 Immunizing peptide - orb15670 from Biorbyt
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