CLIP1
| Gene Symbol | CLIP1 |
|---|---|
| Entrez Gene | 6249 |
| Alt Symbol | CLIP, CLIP-170, CLIP170, CYLN1, RSN |
| Species | Human |
| Gene Type | protein-coding |
| Description | CAP-GLY domain containing linker protein 1 |
| Other Description | CAP-Gly domain-containing linker protein 1|cytoplasmic linker protein 1|cytoplasmic linker protein 170 alpha-2|cytoplasmic linker protein CLIP-170|restin (Reed-Steinberg cell-expressed intermediate filament-associated protein) |
| Swissprots | Q29RG0 Q17RS4 A0AVD3 P30622 |
| Accessions | EAW98320 EAW98321 EAW98322 EAW98323 P30622 AB209115 BAD92352 AF045652 AAC03549 AF045653 AAC03550 AK123769 AK126990 BAG54417 AY563000 AAS75590 BC039081 BC047895 AAH47895 BC062543 AAH62543 BC114213 AAI14214 BC117209 AAI17210 BC126305 AAI26306 BM998166 CB305431 M97501 AAA35693 X64838 CAA46050 XM_005253593 XP_005253650 XM_006719552 XP_006719615 NM_001247997 NP_001234926 NM_002956 NP_002947 NM_198240 NP_937883 |
| Function | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles. |
| Tissue Specificity | Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:1600942}. |
CLIP-170 CRISPR/Cas9 KO Plasmid (h) - sc-401279 from Santa Cruz Biotechnology
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CLIP-170 HDR Plasmid (h) - sc-401279-HDR from Santa Cruz Biotechnology
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CLIP-170 Double Nickase Plasmid (h) - sc-401279-NIC from Santa Cruz Biotechnology
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CLIP-170 Double Nickase Plasmid (h2) - sc-401279-NIC-2 from Santa Cruz Biotechnology
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CLIP-170 CRISPR Activation Plasmid (h) - sc-401279-ACT from Santa Cruz Biotechnology
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CLIP-170 CRISPR Activation Plasmid (h2) - sc-401279-ACT-2 from Santa Cruz Biotechnology
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CLIP-170 Lentiviral Activation Particles (h) - sc-401279-LAC from Santa Cruz Biotechnology
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CLIP-170 Lentiviral Activation Particles (h2) - sc-401279-LAC-2 from Santa Cruz Biotechnology
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CLIP-170 siRNA (h) - sc-43281 from Santa Cruz Biotechnology
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CLIP-170 shRNA Plasmid (h) - sc-43281-SH from Santa Cruz Biotechnology
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CLIP-170 shRNA (h) Lentiviral Particles - sc-43281-V from Santa Cruz Biotechnology
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CLIP170 RNAi - H00006249-R01 from Novus Biologicals
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CLIP170 RNAi - H00006249-R02 from Novus Biologicals
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MISSION® esiRNA - EHU096721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6235 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6235 from Sigma-Aldrich
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CLIP1 siRNA (Human) - CRH4208 from Cohesion Biosciences
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CLIP1 - MBS8220803 from MyBioSource
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shRNA set against Human CLIP1 (NM_002956.2) - SHH265357 from Creative biogene
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shRNA set against Human CLIP1(NM_002956.2) - SHG182689 from Creative biogene
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shRNA set against Human CLIP1(NM_198240.1) - SHG182867 from Creative biogene
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shRNA set against Human CLIP1(NM_002956.2) - SHG183257 from Creative biogene
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Human CLIP1 siRNA - orb264710 from Biorbyt
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CLIP1 shRNA Plasmid (Human) - CHH4208 from Cohesion Biosciences
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CLIP1 miRNA 3'UTR clone - MiUTR1H-02224 from Creative biogene
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