MTOR

Gene Symbol	MTOR
Entrez Gene	2475
Alt Symbol	FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Species	Human
Gene Type	protein-coding
Description	mechanistic target of rapamycin (serine/threonine kinase)
Other Description	FK506 binding protein 12-rapamycin associated protein 2|FK506-binding protein 12-rapamycin complex-associated protein 1|FKBP-rapamycin associated protein|FKBP12-rapamycin complex-associated protein 1|mammalian target of rapamycin|rapamycin and FKBP12 target 1|rapamycin associated protein FRAP2|rapamycin target protein 1|serine/threonine-protein kinase mTOR
Swissprots	P42345 Q96QG3 Q4LE76 Q6LE87 Q5TER1 Q9Y4I3
Accessions	CAC15570 CAC42395 CCW44092 EAW71681 EAW71682 EAW71683 P42345 AA725390 AB209995 BAE06077 AK126762 BAG54371 AK302863 BAG64047 AK304273 BAG65134 BC117166 AAI17167 BP250183 DC403129 L34075 AAA58486 L35478 AAC41713 U88966 AAC39933 XM_005263438 XP_005263495 XM_011541166 XP_011539468 XR_244786 NM_004958 NP_004949
Function	Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through R
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB. {ECO:0000250}.
Tissue Specificity	Expressed in numerous tissues, with highest levels in testis. {ECO:0000269|PubMed:12408816, ECO:0000269|PubMed:7809080}.
Top Pathways	Proteoglycans in cancer, AMPK signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® mTOR siRNA I - 6381 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® mTOR siRNA II - 6556 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

mTOR CRISPR/Cas9 KO Plasmid (h) - sc-400140 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

mTOR HDR Plasmid (h) - sc-400140-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mTOR Double Nickase Plasmid (h) - sc-400140-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mTOR Double Nickase Plasmid (h2) - sc-400140-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mTOR CRISPR Activation Plasmid (h) - sc-400140-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

mTOR CRISPR Activation Plasmid (h2) - sc-400140-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

mTOR Lentiviral Activation Particles (h) - sc-400140-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mTOR Lentiviral Activation Particles (h2) - sc-400140-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mTOR siRNA (h) - sc-35409 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

mTOR shRNA Plasmid (h) - sc-35409-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

mTOR shRNA (h) Lentiviral Particles - sc-35409-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TOR/mTOR RNAi - H00002475-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU101641 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0817 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0816 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0815 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1357 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1279 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1279 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1357 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07317 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07317

MTOR siRNA (Human) - CRH1653 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MTOR (NM_004958.3) - SHH346604 from Creative biogene Category siRNA Species Reactivities Human

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