MTOR

Gene Symbol	MTOR
Entrez Gene	2475
Alt Symbol	FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Species	Human
Gene Type	protein-coding
Description	mechanistic target of rapamycin (serine/threonine kinase)
Other Description	FK506 binding protein 12-rapamycin associated protein 2|FK506-binding protein 12-rapamycin complex-associated protein 1|FKBP-rapamycin associated protein|FKBP12-rapamycin complex-associated protein 1|mammalian target of rapamycin|rapamycin and FKBP12 target 1|rapamycin associated protein FRAP2|rapamycin target protein 1|serine/threonine-protein kinase mTOR
Swissprots	P42345 Q96QG3 Q4LE76 Q6LE87 Q5TER1 Q9Y4I3
Accessions	CAC15570 CAC42395 CCW44092 EAW71681 EAW71682 EAW71683 P42345 AA725390 AB209995 BAE06077 AK126762 BAG54371 AK302863 BAG64047 AK304273 BAG65134 BC117166 AAI17167 BP250183 DC403129 L34075 AAA58486 L35478 AAC41713 U88966 AAC39933 XM_005263438 XP_005263495 XM_011541166 XP_011539468 XR_244786 NM_004958 NP_004949
Function	Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through R
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB. {ECO:0000250}.
Tissue Specificity	Expressed in numerous tissues, with highest levels in testis. {ECO:0000269|PubMed:12408816, ECO:0000269|PubMed:7809080}.
Top Pathways	Proteoglycans in cancer, AMPK signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-mTOR (Ser2448) Sandwich ELISA Kit - 7976 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-mTOR (Ser2481) Sandwich ELISA Kit - 7978 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total mTOR Sandwich ELISA Kit - 7974 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

mTOR (pSer2448) In-Cell ELISA Kit (IR) - ab168539 from Abcam Category ELISA Kit Prices $438.00 Sizes 1 x 96 tests

mTOR (pSer2448) ELISA kit - ab168538 from Abcam Category ELISA Kit Prices $448.00 Sizes 1 x 96 tests Sensitivity = 8 µg/ml Range 15.6 µg/ml - 1000 µg/ml

Mouse/Human/Rat Phospho-MTOR (Thr2446) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1419 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 78-5000 pg/ml

Mouse/Human/Rat Phospho-MTOR (Ser2448) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1569 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 78-5000 pg/ml

Mouse/Human/Rat MTOR ELISA Kit (Cell-Based ELISA) - LS-F2173 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 78-5000 pg/ml

Human MTOR ELISA Kit (Sandwich ELISA) - LS-F8695 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.125 ng/ml Range 78-5000 pg/ml

Rabbit anti-mTOR Antibody, Affinity Purified - PLA0114 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human Phospho-TOR (S2448) DuoSet IC ELISA - DYC1665-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 156.00 - 10,000 pg/mL

Human Phospho-TOR (S2448) DuoSet IC, 5 Plate - DYC1665-5 from R&D Systems Category ELISA Kit

Human FRAP ELISA Kit - abx151585 from Abbexa Category ELISA Kit Sensitivity 0.125 ng/ml Range 0.313 ng/ml - 20 ng/ml

FK506 Binding Protein 12 Rapamycin Associated Protein (FRAP), Human, ELISA Kit - SEB806Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.125ng/mL Range 0.312-20ng/mL

Mammalian target of rapamycin, Human, ELISA Kit - E01M0019 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Mammalian Target of Rapamycin, mTOR, Human, ELISA Kit - E-EL-H1655 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Serine/threonine-protein kinase mTOR, MTOR, Human, ELISA Kit - E14969h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 78-5000 pg/mL

mTOR (Mammalian Target of Rapamycin), Rabbit, ELISA Kit - E-EL-RB1423 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

mTOR (Mammalian Target of Rapamycin), Pig, ELISA Kit - E-EL-P1953 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

mTOR (Mammalian Target of Rapamycin), Monkey, ELISA Kit - E-EL-MK1803 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

Human Phospho-mTOR (S2448) ELISA - PEL-mTOR-S2448 from RayBiotech Category ELISA Kit Prices $481.00, $866.00, $1,924.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Anserine PGA ELISA Kit - AP0094 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

Mtor Colorimetric Cell-Based ELISA Kit - CB5474 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

mTOR (Phospho-Thr2446) Colorimetric Cell-Based ELISA Kit - CBP1451 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

mTOR (Phospho-Ser2448) Colorimetric Cell-Based ELISA Kit - CBP1620 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

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