Gene Symbol | IPPK |
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Entrez Gene | 64768 |
Alt Symbol | C9orf12, INSP5K2, IP5K, IPK1, bA476B13.1 |
Species | Human |
Gene Type | protein-coding |
Description | inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
Other Description | IPK1 homolog|bA476B13.1 (novel protein)|inositol-pentakisphosphate 2-kinase|ins(1,3,4,5,6)P5 2-kinase|insP5 2-kinase |
Swissprots | Q9H7V8 Q5T9F7 Q9H8X2 |
Accessions | CAE91701 EAW62826 Q9H8X2 AF351200 AF351201 AF351202 AAK69692 AF520811 AAM75353 AK023225 BAB14476 AK024267 BAB14866 AK096392 AK123694 BAG53939 BC026154 AAH26154 XM_006717235 XP_006717298 XM_011518920 XP_011517222 NM_022755 NP_073592 |
Function | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed, with high expression in heart, brain, testis and placenta. {ECO:0000269|PubMed:12084730}. |
Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |
IPPK (C-18) - sc-82200 from Santa Cruz Biotechnology
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Anti-IPPK antibody - ab196781 from Abcam
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Anti-IPPK antibody - ab68066 from Abcam
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Anti-IPPK Antibody - LS-C308508 from LifeSpan Bioscience
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Anti-IPPK Antibody (aa366-415) - LS-C135457 from LifeSpan Bioscience
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Anti-IPPK Antibody (aa11-60) - LS-C119269 from LifeSpan Bioscience
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Anti-IPPK Antibody (aa323-372) - LS-C116724 from LifeSpan Bioscience
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IPPK Antibody - NBP1-86712 from Novus Biologicals
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IPPK Antibody - NBP2-16985 from Novus Biologicals
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IPPK Antibody - H00064768-B01 from Novus Biologicals
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IPPK Antibody - H00064768-B01P from Novus Biologicals
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IPPK Antibody - H00064768-A01 from Novus Biologicals
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Anti-IPPK antibody produced in rabbit - SAB2106156 from Sigma-Aldrich
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Anti-IPPK antibody produced in rabbit - HPA020603 from Sigma-Aldrich
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Anti-IPPK, N-Terminal antibody produced in rabbit - SAB4502776 from Sigma-Aldrich
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Anti-IPPK antibody produced in mouse - SAB1400676 from Sigma-Aldrich
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IPPK antibody - middle region (ARP57655_P050) - ARP57655_P050 from Aviva Systems Biology
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IPPK Antibody (OAAF02681) - OAAF02681 from Aviva Systems Biology
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IPPK antibody - 70R-18001 from Fitzgerald
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IPPK antibody - 70R-3497 from Fitzgerald
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IPPK Antibody - abx008059 from Abbexa
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IPPK Antibody - abx013799 from Abbexa
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IPPK antibody - 12603-1-AP from Acris Antibodies
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IPPK antibody - H00064768-A01 from Acris Antibodies
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IPPK antibody - H00064768-B01 from Acris Antibodies
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