Gene Symbol | IPPK |
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Entrez Gene | 64768 |
Alt Symbol | C9orf12, INSP5K2, IP5K, IPK1, bA476B13.1 |
Species | Human |
Gene Type | protein-coding |
Description | inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
Other Description | IPK1 homolog|bA476B13.1 (novel protein)|inositol-pentakisphosphate 2-kinase|ins(1,3,4,5,6)P5 2-kinase|insP5 2-kinase |
Swissprots | Q9H7V8 Q5T9F7 Q9H8X2 |
Accessions | CAE91701 EAW62826 Q9H8X2 AF351200 AF351201 AF351202 AAK69692 AF520811 AAM75353 AK023225 BAB14476 AK024267 BAB14866 AK096392 AK123694 BAG53939 BC026154 AAH26154 XM_006717235 XP_006717298 XM_011518920 XP_011517222 NM_022755 NP_073592 |
Function | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed, with high expression in heart, brain, testis and placenta. {ECO:0000269|PubMed:12084730}. |
Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |
IPPK CRISPR/Cas9 KO Plasmid (h) - sc-409316 from Santa Cruz Biotechnology
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IPPK HDR Plasmid (h) - sc-409316-HDR from Santa Cruz Biotechnology
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IPPK Double Nickase Plasmid (h) - sc-409316-NIC from Santa Cruz Biotechnology
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IPPK Double Nickase Plasmid (h2) - sc-409316-NIC-2 from Santa Cruz Biotechnology
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IPPK CRISPR Activation Plasmid (h) - sc-409316-ACT from Santa Cruz Biotechnology
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IPPK CRISPR Activation Plasmid (h2) - sc-409316-ACT-2 from Santa Cruz Biotechnology
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IPPK Lentiviral Activation Particles (h) - sc-409316-LAC from Santa Cruz Biotechnology
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IPPK Lentiviral Activation Particles (h2) - sc-409316-LAC-2 from Santa Cruz Biotechnology
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IPPK siRNA (h) - sc-75343 from Santa Cruz Biotechnology
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IPPK shRNA Plasmid (h) - sc-75343-SH from Santa Cruz Biotechnology
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IPPK shRNA (h) Lentiviral Particles - sc-75343-V from Santa Cruz Biotechnology
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IPPK RNAi - H00064768-R02 from Novus Biologicals
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MISSION® esiRNA - EHU104941 from Sigma-Aldrich
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MISSION® esiRNA - EHU016851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10737 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10737 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11646 from Sigma-Aldrich
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IPPK siRNA (Human) - CRJ2075 from Cohesion Biosciences
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IPPK - MBS8208136 from MyBioSource
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shRNA set against Human IPPK (NM_022755.5) - SHH320233 from Creative biogene
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Human IPPK siRNA - orb272576 from Biorbyt
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IPPK shRNA Plasmid (Human) - CHJ2075 from Cohesion Biosciences
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IPPK miRNA 3'UTR clone - MiUTR4H-TG04559 from Creative biogene
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