| Gene Symbol |
IPPK
|
| Entrez Gene |
64768
|
| Alt Symbol |
C9orf12, INSP5K2, IP5K, IPK1, bA476B13.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
|
| Other Description |
IPK1 homolog|bA476B13.1 (novel protein)|inositol-pentakisphosphate 2-kinase|ins(1,3,4,5,6)P5 2-kinase|insP5 2-kinase
|
| Swissprots |
Q9H7V8 Q5T9F7 Q9H8X2
|
| Accessions |
CAE91701 EAW62826 Q9H8X2 AF351200 AF351201 AF351202 AAK69692 AF520811 AAM75353 AK023225 BAB14476 AK024267 BAB14866 AK096392 AK123694 BAG53939 BC026154 AAH26154 XM_006717235 XP_006717298 XM_011518920 XP_011517222 NM_022755 NP_073592
|
| Function |
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed, with high expression in heart, brain, testis and placenta. {ECO:0000269|PubMed:12084730}.
|
| Top Pathways |
Inositol phosphate metabolism, Phosphatidylinositol signaling system
|
![Western Blot: IPPK Overexpression Lysate (Adult Normal) [NBL1-12018] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IPPK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7349_IPPK%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12018-img0002.jpg)