| Gene Symbol |
ASH1L
|
| Entrez Gene |
55870
|
| Alt Symbol |
ASH1, ASH1L1, KMT2H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ash1 (absent, small, or homeotic)-like (Drosophila)
|
| Other Description |
ASH1-like protein|absent small and homeotic disks protein 1 homolog|histone-lysine N-methyltransferase ASH1L|lysine N-methyltransferase 2H|probable histone-lysine N-methyltransferase ASH1L
|
| Swissprots |
Q9P2C7 Q9NR48 Q5T715 Q5T714 Q59GP1
|
| Accessions |
EAW53068 Q9NR48 AB037841 BAA92658 AB209068 BAD92305 AF257305 AAF68983 AI912552 AK304873 BAG65610 AK307595 BC172595 AAI72595 BQ883186 CN365042 DA236222 XM_005245337 XP_005245394 XM_006711450 XP_006711513 XM_006711451 XP_006711514 XM_006711452 XP_006711515 XM_011509769 XP_011508071 XM_011509770 XP_011508072 NM_018489 NP_060959
|
| Function |
Histone methyltransferase specifically methylating 'Lys- 36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10860993}. Cell junction, tight junction {ECO:0000269|PubMed:10860993}. Chromosome {ECO:0000305|PubMed:10860993}. Note=The relevance of tight junction localization is however unclear.
|
| Tissue Specificity |
Widely expressed, with highest level in brain, heart and kidney. {ECO:0000269|PubMed:10860993}.
|
| Top Pathways |
Tight junction, Lysine degradation
|