Gene Symbol | ASH1L |
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Entrez Gene | 55870 |
Alt Symbol | ASH1, ASH1L1, KMT2H |
Species | Human |
Gene Type | protein-coding |
Description | ash1 (absent, small, or homeotic)-like (Drosophila) |
Other Description | ASH1-like protein|absent small and homeotic disks protein 1 homolog|histone-lysine N-methyltransferase ASH1L|lysine N-methyltransferase 2H|probable histone-lysine N-methyltransferase ASH1L |
Swissprots | Q9P2C7 Q9NR48 Q5T715 Q5T714 Q59GP1 |
Accessions | EAW53068 Q9NR48 AB037841 BAA92658 AB209068 BAD92305 AF257305 AAF68983 AI912552 AK304873 BAG65610 AK307595 BC172595 AAI72595 BQ883186 CN365042 DA236222 XM_005245337 XP_005245394 XM_006711450 XP_006711513 XM_006711451 XP_006711514 XM_006711452 XP_006711515 XM_011509769 XP_011508071 XM_011509770 XP_011508072 NM_018489 NP_060959 |
Function | Histone methyltransferase specifically methylating 'Lys- 36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10860993}. Cell junction, tight junction {ECO:0000269|PubMed:10860993}. Chromosome {ECO:0000305|PubMed:10860993}. Note=The relevance of tight junction localization is however unclear. |
Tissue Specificity | Widely expressed, with highest level in brain, heart and kidney. {ECO:0000269|PubMed:10860993}. |
Top Pathways | Tight junction, Lysine degradation |
ASH1L CRISPR/Cas9 KO Plasmid (h) - sc-402901 from Santa Cruz Biotechnology
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ASH1L HDR Plasmid (h) - sc-402901-HDR from Santa Cruz Biotechnology
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ASH1L Double Nickase Plasmid (h) - sc-402901-NIC from Santa Cruz Biotechnology
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ASH1L Double Nickase Plasmid (h2) - sc-402901-NIC-2 from Santa Cruz Biotechnology
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ASH1L CRISPR Activation Plasmid (h) - sc-402901-ACT from Santa Cruz Biotechnology
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ASH1L CRISPR Activation Plasmid (h2) - sc-402901-ACT-2 from Santa Cruz Biotechnology
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ASH1L Lentiviral Activation Particles (h) - sc-402901-LAC from Santa Cruz Biotechnology
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ASH1L Lentiviral Activation Particles (h2) - sc-402901-LAC-2 from Santa Cruz Biotechnology
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ASH1L siRNA (h) - sc-88574 from Santa Cruz Biotechnology
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ASH1L shRNA Plasmid (h) - sc-88574-SH from Santa Cruz Biotechnology
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ASH1L shRNA (h) Lentiviral Particles - sc-88574-V from Santa Cruz Biotechnology
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ASH1 RNAi - H00055870-R01 from Novus Biologicals
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MISSION® esiRNA - EHU137581 from Sigma-Aldrich
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MISSION® esiRNA - EHU100901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3596 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3596 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11380 from Sigma-Aldrich
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ASH1L siRNA (Human) - CRJ0984 from Cohesion Biosciences
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ASH1L - MBS8237972 from MyBioSource
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shRNA set against Human ASH1L (NM_018489.2) - SHH241478 from Creative biogene
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shRNA set against Human ASH1L(NM_018489.2) - SHG077347 from Creative biogene
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Human ASH1L siRNA - orb271485 from Biorbyt
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ASH1L shRNA Plasmid (Human) - CHJ0984 from Cohesion Biosciences
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ASH1L miRNA 3'UTR clone - MiUTR1H-00634 from Creative biogene
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