Gene Symbol | MMRN1 |
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Entrez Gene | 22915 |
Alt Symbol | ECM, EMILIN4, GPIa*, MMRN |
Species | Human |
Gene Type | protein-coding |
Description | multimerin 1 |
Other Description | EMILIN-4|elastin microfibril interface located protein 4|elastin microfibril interfacer 4|endothelial cell multimerin|glycoprotein Ia*|multimerin-1 |
Swissprots | Q4W5L1 Q6ZUL9 Q6P3T8 Q13201 |
Accessions | AAY40957 EAX06037 EAX06038 Q13201 AK125557 BAC86201 AK302421 BAH13704 AK313566 BAG36340 BC063848 AAH63848 BM126740 HQ258009 ADR82763 U27109 AAC52065 XM_005262856 XP_005262913 NM_007351 NP_031377 |
Function | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium of blood vessels. Not found in plasma. Found in vascular tissues such as placenta, lung, and liver. {ECO:0000269|PubMed:7629143, ECO:0000269|PubMed:8514871}. |
Human MMRN1 protein fragment - ab161476 from Abcam
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MMRN1 Antibody Blocking Peptide - LS-E4716 from LifeSpan Bioscience
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Recombinant Human MMRN1 Protein - H00022915-Q01 from Novus Biologicals
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MMRN1-Antibody-N-term-Blocking-Peptide - BP17087a from Abgent, a WuXi AppTec company
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ECM Blocking Peptide - 33R-10952 from Fitzgerald
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Human Multimerin 1 Protein - abx068116 from Abbexa
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Multimerin-1 - H00022915-Q01-10 from Acris Antibodies
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Multimerin-1 - H00022915-Q01-25 from Acris Antibodies
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Multimerin 1 (MMRN1), Human - 20-8541 from ARP American Research Products
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MMRN1 fusion protein - ag11919 from Proteintech Group
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MMRN1 fusion protein - Ag11739 from Proteintech Group
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Recombinant Human MMRN1, His-tagged - MMRN1-150H from Creative Biomart
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Recombinant Multimerin 1 (MMRN1) - RPC622Hu01 from Uscn Life Science Inc.
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Recombinant Multimerin 1 (MMRN1) - RPC622Ra01 from Uscn Life Science Inc.
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Recombinant Multimerin 1 (MMRN1) - RPC622Hu01 from Cloud-clone
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Recombinant Human Multimerin-1(MMRN1) ,partial - CSB-YP622645HU CSB-EP622645HU CSB-BP622645HU CSB-MP622645HU from Cusabio
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ECM Blocking Peptide - 3843BP-50 from Biovision
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Multimerin 1 (MMRN1) - RPU142843 from Biomatik
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MMRN1 Recombinant Protein Antigen - NBP1-84014PEP from Novus Biologicals
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MMRN1 Peptide, Human - M34GP09612H from Creative Peptides
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Recombinant Multimerin 1 (MMRN1) - RPU42843 from Biomatik
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MMRN1 Recombinant Protein (OPCD05354) - OPCD05354 from Aviva Systems Biology
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Multimerin 1 (MMRN1), Recombinant Protein - MBS2012009 from MyBioSource
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Multimerin-1 (MMRN1), partial, Recombinant Protein - MBS1287056 from MyBioSource
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