Gene Symbol | MMRN1 |
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Entrez Gene | 22915 |
Alt Symbol | ECM, EMILIN4, GPIa*, MMRN |
Species | Human |
Gene Type | protein-coding |
Description | multimerin 1 |
Other Description | EMILIN-4|elastin microfibril interface located protein 4|elastin microfibril interfacer 4|endothelial cell multimerin|glycoprotein Ia*|multimerin-1 |
Swissprots | Q4W5L1 Q6ZUL9 Q6P3T8 Q13201 |
Accessions | AAY40957 EAX06037 EAX06038 Q13201 AK125557 BAC86201 AK302421 BAH13704 AK313566 BAG36340 BC063848 AAH63848 BM126740 HQ258009 ADR82763 U27109 AAC52065 XM_005262856 XP_005262913 NM_007351 NP_031377 |
Function | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium of blood vessels. Not found in plasma. Found in vascular tissues such as placenta, lung, and liver. {ECO:0000269|PubMed:7629143, ECO:0000269|PubMed:8514871}. |
Multimerin-1 CRISPR/Cas9 KO Plasmid (h) - sc-404741 from Santa Cruz Biotechnology
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Multimerin-1 HDR Plasmid (h) - sc-404741-HDR from Santa Cruz Biotechnology
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Multimerin-1 Double Nickase Plasmid (h) - sc-404741-NIC from Santa Cruz Biotechnology
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Multimerin-1 Double Nickase Plasmid (h2) - sc-404741-NIC-2 from Santa Cruz Biotechnology
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Multimerin-1 CRISPR Activation Plasmid (h) - sc-404741-ACT from Santa Cruz Biotechnology
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Multimerin-1 CRISPR Activation Plasmid (h2) - sc-404741-ACT-2 from Santa Cruz Biotechnology
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Multimerin-1 Lentiviral Activation Particles (h) - sc-404741-LAC from Santa Cruz Biotechnology
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Multimerin-1 Lentiviral Activation Particles (h2) - sc-404741-LAC-2 from Santa Cruz Biotechnology
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Multimerin-1 siRNA (h) - sc-89230 from Santa Cruz Biotechnology
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Multimerin-1 shRNA Plasmid (h) - sc-89230-SH from Santa Cruz Biotechnology
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Multimerin-1 shRNA (h) Lentiviral Particles - sc-89230-V from Santa Cruz Biotechnology
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MMRN1 RNAi - H00022915-R01 from Novus Biologicals
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MISSION® esiRNA - EHU042581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14439 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14439 from Sigma-Aldrich
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MMRN1 siRNA (Human) - CRH7868 from Cohesion Biosciences
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shRNA set against Human MMRN1 (NM_007351.2) - SHH343144 from Creative biogene
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MMRN1 shRNA Plasmid (Human) - CHH7868 from Cohesion Biosciences
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MMRN1 miRNA 3'UTR clone - MiUTR1H-06364 from Creative biogene
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