RNF115

Gene Symbol RNF115
Entrez Gene 27246
Alt Symbol BCA2, ZNF364
Species Human
Gene Type protein-coding
Description ring finger protein 115
Other Description E3 ubiquitin-protein ligase RNF115|rabring 7|zinc finger protein 364
Swissprots Q5T2V9 Q7Z2J2 Q9Y4L5 A8K3Y4
Accessions CAH05282 CAI13717 EAW71437 EAW71438 Q9Y4L5 AF419857 AAP97292 AF542552 AAQ09535 AK290749 BAF83438 AL079312 AL079314 CAB45280 BC054049 AAH54049 BC064903 AAH64903 BG684824 EU446627 ABZ92156 EU446791 ABZ92320 GQ129333 ACT64467 GQ129334 ACT64468 HY099262 XM_005272952 XP_005273009 XM_011509419 XP_011507721 NM_014455 NP_055270
Function E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. {ECO:0000269|PubMed:16288031, ECO:0000269|PubMed:18819927, ECO:0000303|PubMed:23418353}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D0C1}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q9D0C1}.
Tissue Specificity Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. {ECO:0000269|PubMed:16288031}.

RNF115 (D-20) - sc-249866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
extracts.RNF115 (D-20): sc-249866. Western blot analysis of RNF115 expression in NIH/3T3 (A), LADMAC (C) and WEHI-231 (D) nuclear extracts, F9 whole cell lysate (B) and rat skeletal muscle (E) and human heart (F) tissue

Anti-ZNF364 antibody - ab80432 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ZNF364 antibody (ab80432) at 1 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-ZNF364 antibody - ab52016 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-ZNF364 antibody (ab52016) at 0.3 µg/ml + HEPG2 cell lysate (35µg protein in RIPA buffer).

Anti-ZNF364 antibody - ab169039 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-ZNF364 antibody (ab169039) at 1 µg/mlLane 1 : ZNF364 transfected 293T cell lysateLane 2 : non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-mouse HRP conjugated antibody at 1/2500 dilutiondeveloped using the ECL technique

Anti-ZNF364 antibody [EPR14539] - ab187642 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14539
All lanes : Anti-ZNF364 antibody [EPR14539] (ab187642) at 1/1000 dilutionLane 1 : Raw264.7 cell lysateLane 2 : PC-12 cell lysateLane 3 : NIH/3T3 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1000

Anti-RNF115 / BCA2 Antibody (aa97-110) - LS-C55353 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of HEPG2 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-RNF115 / BCA2 Antibody (C-Terminus) - LS-C82457 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

ZNF364 Antibody - NBP1-85586 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ZNF364 Antibody [NBP1-85586] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY415260)

ZNF364 Antibody - NBP1-55055 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ZNF364 Antibody - NB100-41373 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: ZNF364 Antibody [NB100-41373] - (0.3ug/ml) staining of HEPG2 cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

ZNF364 Antibody - H00027246-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: ZNF364 Antibody [H00027246-B01] - analysis of ZNF364 expression in transfected 293T cell line by ZNF364 MaxPab polyclonal antibody (B01). Lane 1: ZNF364 transfected lysate (33.70 KDa). Lane 2: Non-transfected lysate.

ZNF364 Antibody - H00027246-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-RNF115 antibody produced in mouse - SAB1407348 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RNF115: <B>Cat. No. SAB1407348</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~33.4 kDa using RNF115 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-RNF115 antibody produced in rabbit - HPA019130 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RNF115: <B>Cat. No. HPA019130</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in chief cells.

Anti-Rabring 7/BCA2 antibody produced in goat - SAB2500854 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-Rabring 7 / BCA2: <B>Cat. No. SAB2500854</B>: (0.3 μg/mL) staining of HEPG2 cell lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ZNF364 antibody produced in rabbit - SAB2102862 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ZNF364: <B>Cat. No.SAB2102862</B>: ZNF364 in HepG2 cell lysate with ZNF364 antibody at 1.0 μg/mL.

ZNF364 antibody - C-terminal region (ARP43154_P050) - ARP43154_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabring-7--BCA2-Antibody - AF1898a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1898a (0.3 µg/ml) staining of HEPG2 cell lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

RNF115 antibody - orb19287 from Biorbyt

Prices $408.00
Sizes 100 μg
Host Goat
Clonality Polyclonal

Goat Anti-Rabring 7 / BCA2 Antibody (OAEB01659) - OAEB01659 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

ZNF364 antibody - 70R-2797 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

BCA2 Polyclonal Antibody - bs-6757R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF115 antibody - AP16464PU-N from Acris Antibodies

Prices $310.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AP16464PU-N (0.3µg/ml) staining of HEPG2 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

RNF115 antibody - H00027246-B01 from Acris Antibodies

Prices $360.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot analysis of RNF115 expression in transfected 293T cell line (H00027246-T01) by RNF115 MaxPab polyclonal antibody.Lane 1: ZNF364

RNF115 antibody - H00027246-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
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