| Gene Symbol |
RNF115
|
| Entrez Gene |
27246
|
| Alt Symbol |
BCA2, ZNF364
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 115
|
| Other Description |
E3 ubiquitin-protein ligase RNF115|rabring 7|zinc finger protein 364
|
| Swissprots |
Q5T2V9 Q7Z2J2 Q9Y4L5 A8K3Y4
|
| Accessions |
CAH05282 CAI13717 EAW71437 EAW71438 Q9Y4L5 AF419857 AAP97292 AF542552 AAQ09535 AK290749 BAF83438 AL079312 AL079314 CAB45280 BC054049 AAH54049 BC064903 AAH64903 BG684824 EU446627 ABZ92156 EU446791 ABZ92320 GQ129333 ACT64467 GQ129334 ACT64468 HY099262 XM_005272952 XP_005273009 XM_011509419 XP_011507721 NM_014455 NP_055270
|
| Function |
E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. {ECO:0000269|PubMed:16288031, ECO:0000269|PubMed:18819927, ECO:0000303|PubMed:23418353}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D0C1}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q9D0C1}.
|
| Tissue Specificity |
Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. {ECO:0000269|PubMed:16288031}.
|