RNF115

Gene Symbol	RNF115
Entrez Gene	27246
Alt Symbol	BCA2, ZNF364
Species	Human
Gene Type	protein-coding
Description	ring finger protein 115
Other Description	E3 ubiquitin-protein ligase RNF115|rabring 7|zinc finger protein 364
Swissprots	Q5T2V9 Q7Z2J2 Q9Y4L5 A8K3Y4
Accessions	CAH05282 CAI13717 EAW71437 EAW71438 Q9Y4L5 AF419857 AAP97292 AF542552 AAQ09535 AK290749 BAF83438 AL079312 AL079314 CAB45280 BC054049 AAH54049 BC064903 AAH64903 BG684824 EU446627 ABZ92156 EU446791 ABZ92320 GQ129333 ACT64467 GQ129334 ACT64468 HY099262 XM_005272952 XP_005273009 XM_011509419 XP_011507721 NM_014455 NP_055270
Function	E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. {ECO:0000269|PubMed:16288031, ECO:0000269|PubMed:18819927, ECO:0000303|PubMed:23418353}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D0C1}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q9D0C1}.
Tissue Specificity	Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. {ECO:0000269|PubMed:16288031}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ZNF364 full length protein - ab162124 from Abcam Category Protein Source Wheat germ Species Human

RNF115 / BCA2 Antibody Blocking Peptide - LS-E26052 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ZNF364 Protein - H00027246-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF115-Antibody-C-term-Blocking-Peptide - BP19595b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Rabring 7/BCA2 blocking peptide - GTX89285-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

ZNF364 Blocking Peptide - 33R-7433 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ZNF364 Peptide - AC21-0880-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNF115 - H00027246-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF115 - H00027246-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BCA2 Peptide - 45-323P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

RNF115 fusion protein - ag20495 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

RNF115 fusion protein - ag20451 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Rabring 7/BCA2, Peptide - MBS426335 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

ZNF364 Recombinant Protein Antigen - NBP1-85586PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF115 Peptide, Human - M34GP13373H from Creative Peptides Category Peptide Source Synthetic. Species Human

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