SLC12A6

Gene Symbol SLC12A6
Entrez Gene 9990
Alt Symbol ACCPN, KCC3, KCC3A, KCC3B
Species Human
Gene Type protein-coding
Description solute carrier family 12 (potassium/chloride transporter), member 6
Other Description K-Cl cotransporter 3|electroneutral potassium-chloride cotransporter 3|potassium chloride cotransporter 3|potassium chloride cotransporter KCC3a-S3|potassium-chloride transporter-3a|potassium-chloride transporter-3b|solute carrier family 12 (potassium/chloride transporters), member 6|solute carrier family 12 member 6
Swissprots Q2VI00 Q7Z2E7 Q9UFR2 Q9Y665 Q7Z4G5 Q9Y642 Q8TDD4 Q9UHW9 A0AV76
Accessions AAM96215 AAM96216 EAW92295 EAW92296 EAW92297 EAW92298 EAW92299 EAW92300 EAW92301 EAW92302 Q9UHW9 AF105366 AAD39742 AF108831 AAD25337 AF116242 AAF24986 AF477977 AAL85335 AF531258 AAQ10026 AF531259 AAQ10027 AF531260 AAQ10028 AK056019 AK128133 BAG54635 AK292550 BAF85239 AK315283 BAG37692 AL117500 CAB55965 BC033894 BC051709 BC051744 AAH51744 BC070107 AAH70107 BC126241 AAI26242 BC126243 AAI26244 BC150584 AAI50585 BX648195 CAI46042 DQ138323 ABA02873 XM_006720793 XP_006720856 XM_011522267 XP_011520569 XM_011522268 XP_011520570 XM_011522269 XP_011520571 XR_429476 XR_931960 XR_931961 NM_001042494 NP_001035959 NM_001042495 NP_001035960 NM_001042496 NP_001035961 NM_001042497 NP_001035962 NM_005135 NP_005126 NM_133647 NP_598408
Function Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
Subcellular Location Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level). {ECO:0000269|PubMed:16048901}.

KCC3 (C-13) - sc-19424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KCC3 (C-13): sc-19424. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells and Islets of Langerhans.

KCC3 (N-14) - sc-19422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SLC12A6 antibody - ab92951 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SLC12A6 antibody (ab92951) at 1 µg/mlLane 1 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 2 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SLC12A6 antibody - ab89897 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 antibody - ab77338 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SLC12A6 antibody (ab77338) at 0.1 µg/ml + Human Heart lysate (in RIPA buffer) at 35 µg

Anti-SLC12A6 antibody - C-terminal - ab191451 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SLC12A6 antibody - C-terminal (ab191451) at 0.5 µg/mlLane 1 : HeLa cell lysateLane 2 : HUT102 cell lysate

Anti-SLC12A6 antibody - N-terminal - ab170637 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed/ paraffin embedded Human kidney tissue labeling SLC12A6 with ab170637 at a 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

Anti-SLC12A6 antibody - N-terminal - ab190499 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunoprecipitation analysis of Jurkat cell lysate (in RIPA buffer, 1 mg per IP reaction; 20% of IP loaded) labeling SLC12A6 using ab190499 at 6 μg per reaction (lane 1). A Control IgG was used in lane 3. SLC12A6 was also immunoprecipitated with a different rabbit antibody against SLC12A6. For blotting immunoprecipitated SLC12A6, an antibody suitable for WB detection  was used at 1 μg/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-SLC12A6 / KCC3 Antibody (C-Terminus) - LS-C16127 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (C-Terminus) - LS-C24946 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (Internal) - LS-C145084 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (Internal) - LS-C153560 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa13-42, APC) - LS-C240858 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa13-42, AP) - LS-C240857 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa13-42, Biotin) - LS-C240860 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa13-42, FITC) - LS-C240861 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa13-42, PE) - LS-C240865 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa13-42, Azide-free, HRP) - LS-C248174 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa75-125) - LS-C291047 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa20-50) - LS-C325141 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A6 / KCC3 Antibody (aa25-75) - LS-C291046 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human KCC3 by Western Blot. Samples: Whole cell lysate (50 ug) prepared using RIPA buffer from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-KCC3 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-SLC12A6 / KCC3 Antibody (aa375-386) - LS-C55025 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SLC12A6 / KCC3 Antibody (aa1060-1080) - LS-C313277 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of SLC12A6 / KCC3 antibody. Lane 1: HELA Cell Lysate. Lane 2: HUT102 Cell Lysate.

Anti-SLC12A6 / KCC3 Antibody (aa13-42) - LS-C161129 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SLC12A6 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

KCC3/SLC12A6 Antibody - NBP1-06044 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: KCC3/SLC12A6 Antibody [NBP1-06044] - (0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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