Gene Symbol | SLC12A6 |
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Entrez Gene | 9990 |
Alt Symbol | ACCPN, KCC3, KCC3A, KCC3B |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 12 (potassium/chloride transporter), member 6 |
Other Description | K-Cl cotransporter 3|electroneutral potassium-chloride cotransporter 3|potassium chloride cotransporter 3|potassium chloride cotransporter KCC3a-S3|potassium-chloride transporter-3a|potassium-chloride transporter-3b|solute carrier family 12 (potassium/chloride transporters), member 6|solute carrier family 12 member 6 |
Swissprots | Q2VI00 Q7Z2E7 Q9UFR2 Q9Y665 Q7Z4G5 Q9Y642 Q8TDD4 Q9UHW9 A0AV76 |
Accessions | AAM96215 AAM96216 EAW92295 EAW92296 EAW92297 EAW92298 EAW92299 EAW92300 EAW92301 EAW92302 Q9UHW9 AF105366 AAD39742 AF108831 AAD25337 AF116242 AAF24986 AF477977 AAL85335 AF531258 AAQ10026 AF531259 AAQ10027 AF531260 AAQ10028 AK056019 AK128133 BAG54635 AK292550 BAF85239 AK315283 BAG37692 AL117500 CAB55965 BC033894 BC051709 BC051744 AAH51744 BC070107 AAH70107 BC126241 AAI26242 BC126243 AAI26244 BC150584 AAI50585 BX648195 CAI46042 DQ138323 ABA02873 XM_006720793 XP_006720856 XM_011522267 XP_011520569 XM_011522268 XP_011520570 XM_011522269 XP_011520571 XR_429476 XR_931960 XR_931961 NM_001042494 NP_001035959 NM_001042495 NP_001035960 NM_001042496 NP_001035961 NM_001042497 NP_001035962 NM_005135 NP_005126 NM_133647 NP_598408 |
Function | Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. |
Subcellular Location | Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level). {ECO:0000269|PubMed:16048901}. |
Human SLC12A6 protein fragment - ab160749 from Abcam
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SLC12A6 / KCC3 Antibody Blocking Peptide - LS-E1629 from LifeSpan Bioscience
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Recombinant Human KCC3/SLC12A6 Protein - H00009990-Q01 from Novus Biologicals
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SLC12A6-Antibody-N-term-Blocking-peptide - BP12382a from Abgent, a WuXi AppTec company
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KCC3/SLC12A6 blocking peptide - GTX88947-PEP from GeneTex
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SLC12A6 Immunizing peptide - orb16915 from Biorbyt
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SLC12A6 Peptide - AC21-1328-P from Abcore
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SLC12A6 - H00009990-Q01-10 from Acris Antibodies
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SLC12A6 - H00009990-Q01-25 from Acris Antibodies
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KCC3 Peptide - 45-793P from ProSci
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Recombinant Potassium Chloride Cotransporters 3 (KCC3) - RPB628Hu01 from Uscn Life Science Inc.
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Recombinant Potassium Chloride Cotransporters 3 (KCC3) - RPB628Hu01 from Cloud-clone
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SLC12A6 Protein - abx163488 from Abbexa
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KCC3/SLC12A6, Peptide - MBS426314 from MyBioSource
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KCC3/SLC12A6 Recombinant Protein Antigen - NBP1-89282PEP from Novus Biologicals
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SLC12A6 Peptide, Human - M34GP14319H from Creative Peptides
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SLC12A6 Recombinant Protein (OPCD04644) - OPCD04644 from Aviva Systems Biology
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Solute carrier family 12 member 6 (SLC12A6), Recombinant Protein - MBS7101650 from MyBioSource
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