| Gene Symbol |
SLC12A6
|
| Entrez Gene |
9990
|
| Alt Symbol |
ACCPN, KCC3, KCC3A, KCC3B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 12 (potassium/chloride transporter), member 6
|
| Other Description |
K-Cl cotransporter 3|electroneutral potassium-chloride cotransporter 3|potassium chloride cotransporter 3|potassium chloride cotransporter KCC3a-S3|potassium-chloride transporter-3a|potassium-chloride transporter-3b|solute carrier family 12 (potassium/chloride transporters), member 6|solute carrier family 12 member 6
|
| Swissprots |
Q2VI00 Q7Z2E7 Q9UFR2 Q9Y665 Q7Z4G5 Q9Y642 Q8TDD4 Q9UHW9 A0AV76
|
| Accessions |
AAM96215 AAM96216 EAW92295 EAW92296 EAW92297 EAW92298 EAW92299 EAW92300 EAW92301 EAW92302 Q9UHW9 AF105366 AAD39742 AF108831 AAD25337 AF116242 AAF24986 AF477977 AAL85335 AF531258 AAQ10026 AF531259 AAQ10027 AF531260 AAQ10028 AK056019 AK128133 BAG54635 AK292550 BAF85239 AK315283 BAG37692 AL117500 CAB55965 BC033894 BC051709 BC051744 AAH51744 BC070107 AAH70107 BC126241 AAI26242 BC126243 AAI26244 BC150584 AAI50585 BX648195 CAI46042 DQ138323 ABA02873 XM_006720793 XP_006720856 XM_011522267 XP_011520569 XM_011522268 XP_011520570 XM_011522269 XP_011520571 XR_429476 XR_931960 XR_931961 NM_001042494 NP_001035959 NM_001042495 NP_001035960 NM_001042496 NP_001035961 NM_001042497 NP_001035962 NM_005135 NP_005126 NM_133647 NP_598408
|
| Function |
Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
|
| Subcellular Location |
Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level). {ECO:0000269|PubMed:16048901}.
|
![Western Blot: SLC12A6/KCC3 Overexpression Lysate (Adult Normal) [NBP2-10905] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC12A6/KCC3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9592_SLC12A6-KCC3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10905-img0001.jpg)